PMID- 20547790
OWN - NLM
STAT- MEDLINE
DCOM- 20101201
LR  - 20211020
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Print)
IS  - 0066-4804 (Linking)
VI  - 54
IP  - 9
DP  - 2010 Sep
TI  - Therapeutic drug monitoring of posaconazole in hematology patients: experience 
      with a new high-performance liquid chromatography-based method.
PG  - 4029-32
LID - 10.1128/AAC.00150-10 [doi]
AB  - Parallel administration of the proton pump inhibitor (PPI) esomeprazole has been 
      shown to decrease oral bioavailability of posaconazole in healthy volunteers. We 
      prospectively analyzed serum samples (n = 59) obtained from hematology patients 
      (n = 27) under posaconazole prophylaxis. Patients treated concomitantly with 
      pantoprazole had significantly lower posaconazole levels than patients without 
      PPI treatment (median levels of 630 microg/liter versus 1,125 microg/liter, 
      respectively). These results suggest that drug monitoring is relevant when 
      posaconazole and pantoprazole are administered concomitantly.
FAU - Neubauer, Werner Christian
AU  - Neubauer WC
AD  - University Medical Center Freiburg, Department of Hematology & Oncology, 
      Freiburg, Germany. werner.neubauer@uniklinik-freiburg.de
FAU - Engelhardt, Monika
AU  - Engelhardt M
FAU - Konig, Armin
AU  - Konig A
FAU - Hieke, Stefanie
AU  - Hieke S
FAU - Jung, Manfred
AU  - Jung M
FAU - Bertz, Hartmut
AU  - Bertz H
FAU - Kummerer, Klaus
AU  - Kummerer K
LA  - eng
PT  - Journal Article
DEP - 20100614
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Antifungal Agents)
RN  - 0 (Triazoles)
RN  - 6TK1G07BHZ (posaconazole)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antifungal Agents/*therapeutic use
MH  - Chromatography, High Pressure Liquid
MH  - Female
MH  - Hematologic Neoplasms/*microbiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mycoses/drug therapy
MH  - Prospective Studies
MH  - Triazoles/*therapeutic use
PMC - PMC2934950
EDAT- 2010/06/16 06:00
MHDA- 2010/12/14 06:00
PMCR- 2011/03/01
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - AAC.00150-10 [pii]
AID - 0150-10 [pii]
AID - 10.1128/AAC.00150-10 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 2010 Sep;54(9):4029-32. doi: 10.1128/AAC.00150-10. 
      Epub 2010 Jun 14.