PMID- 20548266
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20220318
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 90
IP  - 3
DP  - 2010 Aug 15
TI  - Pediatric kidney transplantation: analysis of donor age, HLA match, and 
      posttransplant non-Hodgkin lymphoma: a collaborative transplant study report.
PG  - 292-7
LID - 10.1097/TP.0b013e3181e46a22 [doi]
AB  - BACKGROUND: The impact and relationship of donor age, human leukocyte antigen 
      (HLA) matching, and posttransplant non-Hodgkin lymphoma in pediatric kidney 
      recipients are not completely understood. METHODS: We analyzed Collaborative 
      Transplant Study data from 9209 pediatric kidney transplant recipients to examine 
      the effects of donor age and HLA match on graft survival and the relationship 
      between HLA match and occurrence of non-Hodgkin lymphoma. RESULTS: Survival rates 
      using donors aged 11 to 17, 18 to 34, or 35 to 49 years were similar. Cox 
      regression analysis showed that two HLA-DR mismatches were associated with lower 
      graft survival in transplants performed during 1988 to 1997 (P<0.001) but not 
      during the 1998 to 2007 period (P=0.95). A hierarchical relationship was observed 
      for the effect of increasing numbers of combined HLA-A+B+DR mismatches on graft 
      survival during the 1988 to 1997 (P<0.001) and the 1998 to 2007 period (P<0.001). 
      An association between two HLA-DR mismatches and non-Hodgkin lymphoma was 
      demonstrated by multivariate analysis (hazard ratio for 2 vs. 0-1 DR mismatches 
      2.04, P=0.021), and the result was consistent during both 10-year periods. 
      CONCLUSION: We recommend that (1) kidneys from deceased donors up to 49 years be 
      allocated to children, (2) an acceptable HLA-A+B+DR match be attempted in 
      patients with relatively common HLA phenotypes, and (3) transplants with two 
      HLA-DR mismatches be avoided to reduce the risk of posttransplant non-Hodgkin 
      lymphoma.
FAU - Opelz, Gerhard
AU  - Opelz G
AD  - Department of Transplantation Immunology, University of Heidelberg, Heidelberg, 
      Germany. gerhard.opelz@med.uni-heidelberg.de
FAU - Dohler, Bernd
AU  - Dohler B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Transplantation. 2010 Aug 15;90(3):244-5. PMID: 20555309
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Child
MH  - Cooperative Behavior
MH  - Databases as Topic
MH  - *Donor Selection
MH  - Female
MH  - *Graft Survival/immunology
MH  - HLA Antigens/*immunology
MH  - Health Care Rationing
MH  - *Histocompatibility Testing
MH  - Humans
MH  - International Cooperation
MH  - Kidney Failure, Chronic/*surgery
MH  - *Kidney Transplantation/adverse effects
MH  - Lymphoma, Non-Hodgkin/*etiology/immunology/prevention & control
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Tissue Donors/*supply & distribution
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2010/06/16 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - 10.1097/TP.0b013e3181e46a22 [doi]
PST - ppublish
SO  - Transplantation. 2010 Aug 15;90(3):292-7. doi: 10.1097/TP.0b013e3181e46a22.