PMID- 20548803
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20220408
IS  - 1526-6702 (Electronic)
IS  - 0730-2347 (Print)
IS  - 0730-2347 (Linking)
VI  - 37
IP  - 3
DP  - 2010
TI  - Low pulse pressure as a predictor of death in patients with mild to advanced 
      heart failure.
PG  - 284-90
AB  - The prognostic value of pulse pressure has been investigated in heart-failure 
      patients. Low pulse pressure in advanced heart failure and high pulse pressure in 
      mild heart failure have been separately linked to increased mortality rates. We 
      prospectively investigated an association between pulse pressure and 2-year 
      cardiovascular death in an entire heart-failure population. We prospectively 
      enrolled 225 heart-failure patients (New York Heart Association [NYHA] functional 
      class, I-IV; mean age, 56.5 +/- 12.3 yr; 188 men). The patients' blood pressures 
      were measured in accordance with recommended guidelines. Pulse pressures were 
      calculated as the difference between systolic and diastolic blood pressure 
      values. The patients were monitored for a mean period of 670 +/- 42 days for the 
      occurrence of cardiovascular death. All patients were divided into quartiles 
      according to their pulse pressures (<35, 35-45, 46-55, and >55 mmHg). Pulse 
      pressure decreased as NYHA class worsened (P <0.001). Patients in the <35-mmHg 
      quartile had the lowest plasma sodium concentrations, left ventricular ejection 
      fractions, and systolic myocardial velocities upon echocardiography; and the 
      highest left ventricular dimensions, early diastolic/late diastolic filling 
      velocity ratios, and peak early/peak late diastolic myocardial velocity ratios. 
      Pulse pressure independently predicted death in the patients with advanced heart 
      failure and in the entire population. Upon receiver operating characteristic 
      analysis, a 30-mmHg cutoff value for pulse pressure predicted death with 83.7% 
      sensitivity and 79.7% specificity. Pulse pressure is easily calculated and 
      enables the prediction of cardiovascular death in patients with mild to advanced 
      heart failure. Pulse pressure can be used reliably as a prognostic marker in 
      clinical practice.
FAU - Yildiran, Tansel
AU  - Yildiran T
AD  - Department of Cardiology, Medical Faculty, Cukurova University, 01330 Adana, 
      Turkey. drtansel@yahoo.com
FAU - Koc, Mevlut
AU  - Koc M
FAU - Bozkurt, Abdi
AU  - Bozkurt A
FAU - Sahin, Durmus Yildiray
AU  - Sahin DY
FAU - Unal, Ilker
AU  - Unal I
FAU - Acarturk, Esmeray
AU  - Acarturk E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tex Heart Inst J
JT  - Texas Heart Institute journal
JID - 8214622
RN  - 0 (Biomarkers)
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - *Blood Pressure
MH  - Blood Pressure Determination/instrumentation
MH  - Chi-Square Distribution
MH  - Female
MH  - Heart Failure/blood/*mortality/*physiopathology
MH  - Heart Rate
MH  - Humans
MH  - Linear Models
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Sodium/blood
MH  - Sphygmomanometers
MH  - Stroke Volume
MH  - Time Factors
MH  - Turkey
MH  - Ventricular Function, Left
PMC - PMC2879196
OTO - NOTNLM
OT  - Blood pressure/physiology
OT  - cardiovascular diseases/mortality/physiopathology
OT  - epidemiologic methods
OT  - heart failure/epidemiology/etiology/physiopathology
OT  - multivariate analysis
OT  - predictive value of tests
OT  - prospective studies
OT  - pulse/physiology
OT  - reference values
OT  - risk factors
EDAT- 2010/06/16 06:00
MHDA- 2010/09/29 06:00
PMCR- 2010/01/01
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - 0010801-201006000-00005 [pii]
PST - ppublish
SO  - Tex Heart Inst J. 2010;37(3):284-90.