PMID- 20550778
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20111117
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 14
IP  - 7
DP  - 2010 Jul
TI  - Human leukocyte antigen typing in tuberculous rheumatism: Poncet's disease.
PG  - 916-20
AB  - SETTING: Tuberculous rheumatism (Poncet's disease) is a reactive polyarthropathy 
      associated with extra-pulmonary and pulmonary tuberculosis (TB) without evidence 
      of mycobacterial infection of the involved joints. As all patients with TB do not 
      present with this peculiar clinical feature, a genetic susceptibility is 
      suspected. OBJECTIVE: To determine the major histocompatibility complex (MHC) 
      class I and II alleles in Mexican mestizo patients with Poncet's disease. DESIGN: 
      In this case-control study of 16 Mexican mestizo patients diagnosed with Poncet's 
      disease and 99 ethnically matched healthy controls, high resolution human 
      leukocyte antigen (HLA) typing was performed for HLA-A, B, DR and DQ by 
      polymerase chain reaction. HLA-DRB1 and HLA-DQB1 subtypes were performed by 
      sequence-specific oligonucleotide probe hybridization. RESULTS: A significantly 
      increased frequency of HLA-B27 (corrected P = 0.01) and DQB1*0301 (corrected P = 
      0.0009) alleles and decreased frequency of HLA-DQB1*0302 (corrected P = 0.00001) 
      were identified in patients compared to healthy controls. CONCLUSION: These data 
      suggest that genes located within the MHC may play a role in the susceptibility 
      to Poncet's disease in patients diagnosed with TB.
FAU - Lugo-Zamudio, G E
AU  - Lugo-Zamudio GE
AD  - Department of Rheumatology, Hospital Juarez de Mexico, Mexico DF, Mexico. 
      gelz1@prodigy.net.mx
FAU - Yamamoto-Furusho, J K
AU  - Yamamoto-Furusho JK
FAU - Delgado-Ochoa, D
AU  - Delgado-Ochoa D
FAU - Nunez-Farfan, R M
AU  - Nunez-Farfan RM
FAU - Vargas-Alarcon, G
AU  - Vargas-Alarcon G
FAU - Barbosa-Cobos, R E
AU  - Barbosa-Cobos RE
FAU - Granados, J
AU  - Granados J
LA  - eng
PT  - Journal Article
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal 
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Genes, MHC Class I/genetics
MH  - Genes, MHC Class II/genetics
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-B27 Antigen/genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Oligonucleotide Probes
MH  - Polymerase Chain Reaction
MH  - Tuberculosis, Osteoarticular/*genetics
MH  - Young Adult
EDAT- 2010/06/17 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2010 Jul;14(7):916-20.