PMID- 20550983
OWN - NLM
STAT- MEDLINE
DCOM- 20110119
LR  - 20211020
IS  - 1558-2531 (Electronic)
IS  - 0018-9294 (Print)
IS  - 0018-9294 (Linking)
VI  - 57
IP  - 10
DP  - 2010 Oct
TI  - A PDMS-based conical-well microelectrode array for surface stimulation and 
      recording of neural tissues.
PG  - 2485-94
LID - 10.1109/TBME.2010.2052617 [doi]
AB  - A method for fabricating polydimethylsiloxane (PDMS) based microelectrode arrays 
      (MEAs) featuring novel conical-well microelectrodes is described. The fabrication 
      technique is reliable and efficient, and facilitates controllability over both 
      the depth and the slope of the conical wells. Because of the high-PDMS elasticity 
      (as compared to other MEA substrate materials), this type of compliant MEA is 
      promising for acute and chronic implantation in applications that benefit from 
      conformable device contact with biological tissue surfaces and from minimal 
      tissue damage. The primary advantage of the conical-well microelectrodes--when 
      compared to planar electrodes--is that they provide an improved contact on tissue 
      surface, which potentially provides isolation of the electrode microenvironment 
      for better electrical interfacing. The raised wells increase the uniformity of 
      current density distributions at both the electrode and tissue surfaces, and they 
      also protect the electrode material from mechanical damage (e.g., from rubbing 
      against the tissue). Using this technique, electrodes have been fabricated with 
      diameters as small as 10 mum and arrays have been fabricated with center-to-center 
      electrode spacings of 60 mum. Experimental results are presented, describing 
      electrode-profile characterization, electrode-impedance measurement, and 
      MEA-performance evaluation on fiber bundle recruitment in spinal cord white 
      matter.
FAU - Guo, Liang
AU  - Guo L
AD  - Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of 
      Technology, Atlanta, GA 30332, USA. liang.guo@gatech.edu
FAU - Meacham, Kathleen W
AU  - Meacham KW
FAU - Hochman, Shawn
AU  - Hochman S
FAU - DeWeerth, Stephen P
AU  - DeWeerth SP
LA  - eng
GR  - R01 EB006179/EB/NIBIB NIH HHS/United States
GR  - R01 EB006179-03/EB/NIBIB NIH HHS/United States
GR  - T32 GM008169/GM/NIGMS NIH HHS/United States
GR  - EB006179/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100614
PL  - United States
TA  - IEEE Trans Biomed Eng
JT  - IEEE transactions on bio-medical engineering
JID - 0012737
RN  - 0 (Dimethylpolysiloxanes)
RN  - 63148-62-9 (baysilon)
SB  - IM
MH  - Animals
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Electric Impedance
MH  - Electric Stimulation/*instrumentation
MH  - Materials Testing
MH  - Microelectrodes
MH  - *Neural Prostheses
MH  - *Prosthesis Design
MH  - Rats
PMC - PMC5839322
MID - NIHMS349290
EDAT- 2010/06/17 06:00
MHDA- 2011/01/20 06:00
PMCR- 2018/03/06
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2011/01/20 06:00 [medline]
PHST- 2018/03/06 00:00 [pmc-release]
AID - 10.1109/TBME.2010.2052617 [doi]
PST - ppublish
SO  - IEEE Trans Biomed Eng. 2010 Oct;57(10):2485-94. doi: 10.1109/TBME.2010.2052617. 
      Epub 2010 Jun 14.