PMID- 20552051
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 2
DP  - 2010
TI  - 3alpha-androstanediol, but not testosterone, attenuates age-related decrements in 
      cognitive, anxiety, and depressive behavior of male rats.
PG  - 15
LID - 10.3389/fnagi.2010.00015 [doi]
LID - 15
AB  - Some hippocampally-influenced affective and/or cognitive processes decline with 
      aging. The role of androgens in this process is of interest. Testosterone (T) is 
      aromatized to estrogen, and reduced to dihydrotestosterone (DHT), which is 
      converted to 5alpha-androstane, 3alpha, 17alpha-diol (3alpha-diol). To determine 
      the extent to which some age-related decline in hippocampally-influenced 
      behaviors may be due to androgens, we examined the effects of variation in 
      androgen levels due to age, gonadectomy, and androgen replacement on cognitive 
      (inhibitory avoidance, Morris water maze) and affective (defensive freezing, 
      forced swim) behavior among young (4 months), middle-aged (13 months), and aged 
      (24 months) male rats. Plasma and hippocampal levels of androgens were 
      determined. In experiment 1, comparisons were made between 4-, 13-, and 
      24-month-old rats that were intact or gonadectomized (GDX) and administered a 
      T-filled or empty silastic capsule. There was age-related decline in performance 
      of the inhibitory avoidance, water maze, defensive freezing, and forced swim 
      tasks, and hippocampal 3alpha-diol levels. Chronic, long-term (1-4 weeks) 
      T-replacement reversed the effects of GDX in 4- and 13-month-old, but not 
      24-month-old, rats in the inhibitory avoidance task. Experiments 2 and 3 assessed 
      whether acute subcutaneous T or 3alpha-diol, respectively, could reverse 
      age-associated decline in performance. 3alpha-diol, but not T, compared to 
      vehicle, improved performance in the inhibitory avoidance, water maze, forced 
      swim, and defensive freezing tasks, irrespective of age. Thus, age is associated 
      with a decrease in 3alpha-diol production and 3alpha-diol administration 
      reinstates cognitive and affective performance of aged male rats.
FAU - Frye, Cheryl A
AU  - Frye CA
AD  - Department of Psychology, University at Albany-SUNY Albany, NY, USA.
FAU - Edinger, Kassandra L
AU  - Edinger KL
FAU - Lephart, Edwin D
AU  - Lephart ED
FAU - Walf, Alicia A
AU  - Walf AA
LA  - eng
GR  - R01 MH067698/MH/NIMH NIH HHS/United States
GR  - R56 MH067698/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20100408
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC2874398
OTO - NOTNLM
OT  - 3alpha-diol
OT  - affect
OT  - aging
OT  - androgens
OT  - cognition
OT  - depression
OT  - testosterone
EDAT- 2010/06/17 06:00
MHDA- 2010/06/17 06:01
PMCR- 2010/01/01
CRDT- 2010/06/17 06:00
PHST- 2009/11/06 00:00 [received]
PHST- 2010/03/16 00:00 [accepted]
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/06/17 06:01 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2010.00015 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2010 Apr 8;2:15. doi: 10.3389/fnagi.2010.00015. eCollection 
      2010.