PMID- 20552589
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20211020
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 33
IP  - 6
DP  - 2010 Jun
TI  - Improving myocardial perfusion by percutaneous coronary intervention reduces 
      central sympathetic activity in stable angina.
PG  - E16-21
LID - 10.1002/clc.20676 [doi]
AB  - BACKGROUND: By stimulating sympathetic afferents, repetitive myocardial ischemia 
      induces a state of increased sympathetic tone. HYPOTHESIS: Removing the ischemic 
      trigger by revascularization using percutaneous coronary intervention (PCI) might 
      thus reduce central sympathetic activity in symptomatically stable angina 
      patients. METHODS: A total of 20 patients with stable angina > or = New York 
      Heart Association (NYHA) class II with persistent symptoms despite maximal 
      pharmacological therapy and a clinical indication for PCI, were included in our 
      study. Sympathetic nervous system activity was measured before and 1 month after 
      PCI by a combination of techniques: direct muscle sympathetic nerve activity 
      (MSNA), neurochemical (plasma catecholamine levels), and heart rate variability 
      (HRV). RESULTS: All patients completed the study. After PCI there was a 
      significant reduction in MSNA (pre-PCI 72 +/- 4 to post-PCI 53 +/- 4 burst/100 
      beats, P < .05) and low frequency/high frequency (LF/HF) ratio (3.7 +/- 0.6 vs 
      2.4 +/- 0.4, P < .05) consistent with a decline in sympathetic activity. Plasma 
      norepinephrine levels were reduced after PCI, but this difference did not reach 
      statistical significance (1.84 +/- 0.17 vs 1.73 +/- 0.13 nmol/L, P = not 
      significant). CONCLUSION: Coronary revascularization by PCI reduces sympathetic 
      activity in patients with established myocardial ischemia.
FAU - Gomes, Marc E
AU  - Gomes ME
AD  - Department of Cardiology, Radboud University Nijmegen Medical Centre, Nijmegen, 
      The Netherlands.
FAU - Aengevaeren, Wim R
AU  - Aengevaeren WR
FAU - Lenders, Jacques W
AU  - Lenders JW
FAU - Verheugt, Freek W
AU  - Verheugt FW
FAU - Smits, Paul
AU  - Smits P
FAU - Tack, Cees J
AU  - Tack CJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Biomarkers)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Aged
MH  - Angina Pectoris/blood/etiology/physiopathology/*therapy
MH  - *Angioplasty, Balloon, Coronary
MH  - Biomarkers/blood
MH  - *Coronary Circulation
MH  - Electric Stimulation
MH  - Electrocardiography
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/innervation
MH  - Myocardial Ischemia/blood/complications/physiopathology/*therapy
MH  - Netherlands
MH  - Norepinephrine/blood
MH  - Severity of Illness Index
MH  - Sympathetic Nervous System/metabolism/*physiopathology
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC6653192
EDAT- 2010/06/17 06:00
MHDA- 2010/10/05 06:00
PMCR- 2010/04/30
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
PHST- 2010/04/30 00:00 [pmc-release]
AID - CLC20676 [pii]
AID - 10.1002/clc.20676 [doi]
PST - ppublish
SO  - Clin Cardiol. 2010 Jun;33(6):E16-21. doi: 10.1002/clc.20676.