PMID- 20552629
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20211020
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 33
IP  - 6
DP  - 2010 Jun
TI  - Case report: the effect of proton pump inhibitor administration on hemodynamics 
      in a cardiac intensive care unit.
PG  - E111-3
LID - 10.1002/clc.20690 [doi]
AB  - Ex vivo studies have suggested that high dose proton pump inhibitors (PPI) may 
      have negative inotropic effects in myocardial tissue. We sought to investigate 
      this concept in a real-world clinical setting. In this case series, we enrolled 
      critically ill patients in the coronary and cardiothoracic intensive care units 
      who had a preexisting pulmonary artery (PA) catheter in place for hemodynamic 
      monitoring and were on a PPI for prespecified clinical indications. Hemodynamic 
      measurements were made at baseline and then at 15 minute intervals for 1 hour 
      after PPI administration. A total of 18 patients were evaluated; 72% were male 
      with a mean age of 59.9 years. A total of 9 patients were evaluated on 2 
      consecutive days, yielding 26 patient-exposures to the medication. The majority 
      of patients (72%) were receiving 1 or more inotropic agents (n = 6), a 
      vasopressor (n = 4), or both (n = 4). When compared to baseline values, there was 
      no significant change in mean arterial pressure (baseline 80 +/- 11 mm Hg), heart 
      rate (87 +/- 11 bpm), or Fick cardiac index (2.7 +/- 1.8 L/min/m(2)). Mean PA 
      pressure did decrease transiently at 45 minutes following PPI administration 
      (28.5 +/- 7.7 mm Hg at baseline vs 26.5 +/- 7.5 mm Hg, P = 0.017), but is 
      unlikely to be of clinical significance. In conclusion, these data suggest that 
      IV PPIs do not immediately impact important hemodynamic parameters and are likely 
      safe in a high-risk intensive care setting.
FAU - Booher, Anna M
AU  - Booher AM
AD  - Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, 
      USA. amanion@med.umich.edu
FAU - Dorsch, Michael
AU  - Dorsch M
FAU - Gurm, Hitinder S
AU  - Gurm HS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure/drug effects
MH  - Catheterization, Swan-Ganz
MH  - *Coronary Care Units
MH  - *Critical Care
MH  - Female
MH  - Heart Rate/drug effects
MH  - Hemodynamics/*drug effects
MH  - Humans
MH  - Injections, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*administration & dosage/adverse effects
MH  - Risk Assessment
MH  - Time Factors
PMC - PMC6653714
EDAT- 2010/06/17 06:00
MHDA- 2010/10/05 06:00
PMCR- 2010/04/30
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
PHST- 2010/04/30 00:00 [pmc-release]
AID - CLC20690 [pii]
AID - 10.1002/clc.20690 [doi]
PST - ppublish
SO  - Clin Cardiol. 2010 Jun;33(6):E111-3. doi: 10.1002/clc.20690.