PMID- 20553084
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20170308
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 10 Suppl
DP  - 2009 Dec
TI  - Lack of association between risk of biliary tract cancer and circulating IGF 
      (Insulin-like Growth Factor) -I, IGF-II or IGFBP-3 (IGF-binding Protein-3): A 
      nested case-control study in a large scale cohort study in Japan.
PG  - 63-7
AB  - Biliary tract cancer, encompassing gallbladder and bile duct cancers, has a poor 
      prognosis, but little is known of the etiology. A nested case-control study was 
      here conducted to evaluate the association between serum levels of IGF-I, IGF-II 
      and IGFBP-3 and death from biliary tract cancer. In a large scale cohort study, 
      35 gallbladder and 42 bile duct cancers were observed during the follow-up. For 
      each subject in the case group, 1-3 control subjects (228 in total) were selected 
      randomly, matched for sex, age (as near as possible) and residential area. The 
      subjects were divided into tertiles by circulating levels of IGF-I, IGF-II or 
      IGFBP-3. Using conditional logistic regression, risks among the tertiles were 
      compared adjusted for defecation, smoking and drinking habits. No remarkable 
      differences in risks of gallbladder or bile duct cancer were observed among 
      tertiles of IGF-I or IGF-II, and no remarkable trend was observed. Circulating 
      IGFBP-3 showed an inverse U-shape association with gallbladder cancer and a 
      U-shaped one with bile duct cancer. Associations between IGF-I or IGF-II and 
      gallbladder or bile duct cancer thus were lacking or very weak. The observed U- 
      and inverse U-shaped association of IGFBP-3 with the cancers is not suggestive of 
      any meaningful relationships.
FAU - Yagyu, Kiyoko
AU  - Yagyu K
AD  - Department of Public Health, Aichi Medical University School of Medicine, Japan. 
      kikuchis@aichi-med-u.ac.jp
FAU - Kikuchi, Shogo
AU  - Kikuchi S
FAU - Lin, Yingsong
AU  - Lin Y
FAU - Ishibashi, Teruo
AU  - Ishibashi T
FAU - Obata, Yuki
AU  - Obata Y
FAU - Kurosawa, Michiko
AU  - Kurosawa M
FAU - Ito, Yoshinori
AU  - Ito Y
FAU - Watanabe, Yoshiyuki
AU  - Watanabe Y
FAU - Inaba, Yutaka
AU  - Inaba Y
FAU - Tajima, Kazuo
AU  - Tajima K
FAU - Nakachi, Kei
AU  - Nakachi K
FAU - Tamakoshi, Akiko
AU  - Tamakoshi A
CN  - JACC Study Group
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biliary Tract Neoplasms/*blood/epidemiology/*mortality
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Insulin-Like Growth Factor II/*metabolism
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Prognosis
MH  - Risk Factors
MH  - Survival Rate
FIR - Tamakoshi, Akiko
IR  - Tamakoshi A
FIR - Mori, Mitsuru
IR  - Mori M
FIR - Sakauchi, Fumio
IR  - Sakauchi F
FIR - Motohashi, Yutaka
IR  - Motohashi Y
FIR - Tsuji, Ichiro
IR  - Tsuji I
FIR - Nakamura, Yosikazu
IR  - Nakamura Y
FIR - Iso, Hiroyasu
IR  - Iso H
FIR - Mikami, Haruo
IR  - Mikami H
FIR - Kurosawa, Michiko
IR  - Kurosawa M
FIR - Hoshiyama, Yoshiharu
IR  - Hoshiyama Y
FIR - Tanabe, Naohito
IR  - Tanabe N
FIR - Tamakoshi, Koji
IR  - Tamakoshi K
FIR - Wakai, Kenji
IR  - Wakai K
FIR - Tokudome, Shinkan
IR  - Tokudome S
FIR - Suzuki, Koji
IR  - Suzuki K
FIR - Hashimoto, Shuji
IR  - Hashimoto S
FIR - Kikuchi, Shogo
IR  - Kikuchi S
FIR - Wada, Yasuhiko
IR  - Wada Y
FIR - Kawamura, Takashi
IR  - Kawamura T
FIR - Watanabe, Yoshiyuki
IR  - Watanabe Y
FIR - Ozasa, Kotaro
IR  - Ozasa K
FIR - Miki, Tsuneharu
IR  - Miki T
FIR - Date, Chigusa
IR  - Date C
FIR - Sakata, Kiyomi
IR  - Sakata K
FIR - Kurozawa, Yoichi
IR  - Kurozawa Y
FIR - Yoshimura, Takesumi
IR  - Yoshimura T
FIR - Fujino, Yoshihisa
IR  - Fujino Y
FIR - Shibata, Akira
IR  - Shibata A
FIR - Okamoto, Naoyuki
IR  - Okamoto N
FIR - Shio, Hideo
IR  - Shio H
EDAT- 2010/07/06 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
AID - 25096 [pii]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2009 Dec;10 Suppl:63-7.