PMID- 20553229
OWN - NLM
STAT- MEDLINE
DCOM- 20101201
LR  - 20220331
IS  - 2212-4055 (Electronic)
IS  - 1871-5281 (Linking)
VI  - 9
IP  - 3
DP  - 2010 Jul
TI  - The role of neurotrophins in inflammation and allergy.
PG  - 173-80
AB  - Allergic inflammation is the result of a specific pattern of cellular and humoral 
      responses leading to the activation of the innate and adaptive immune system 
      which, in turn, results in physiological and structural changes affecting target 
      tissues such as the airways and the skin. Eosinophils activation and production 
      of soluble mediators such as IgE antibodies is a pivotal feature in the 
      pathophysiology of allergic diseases. In the past few years, however, convincing 
      evidence has shown that neurons and other neurosensory structures are not only a 
      target of the inflammatory process but also participate in the regulation of 
      immune responses by actively releasing soluble mediators. The main products of 
      these activated sensory neurons are a family of protein growth factors called 
      neurotrophins. They were first isolated in the central nervous system and 
      identified as important factors for the survival and differentiation of neurons 
      during fetal and post-natal development as well as neuronal maintenance later in 
      life. Four members of this family have been identified and well defined: nerve 
      growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 
      (NT-3), and neurotrophin 4/5 (NT-4/5). Neurotrophins play a critical role in the 
      bidirectional signaling mechanisms between immune cells and the neurosensory 
      network structures in the airways and the skin. Pruritus and airway 
      hyperresponsiveness (AHR), two major features of atopic dermatitis and asthma, 
      respectively, are associated with the disruption of the neurosensory network 
      activities. In this review we provide a comprehensive description of the 
      neuroimmune interactions underlying the pathophysiological mechanisms of allergic 
      and inflammatory diseases.
FAU - Scuri, Mario
AU  - Scuri M
AD  - Department of Pediatrics, West Virginia University School of Medicine, 
      Morgantown, USA. mscuri@hsc.wvu.edu
FAU - Samsell, Lennie
AU  - Samsell L
FAU - Piedimonte, Giovanni
AU  - Piedimonte G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Inflamm Allergy Drug Targets
JT  - Inflammation & allergy drug targets
JID - 101266886
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Humans
MH  - Hypersensitivity/*immunology/metabolism
MH  - Inflammation/immunology/metabolism
MH  - Nerve Growth Factors/*immunology/physiology
MH  - Neuroimmunomodulation
MH  - Receptors, Nerve Growth Factor/immunology/metabolism
EDAT- 2010/06/18 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/05/25 00:00 [received]
PHST- 2010/05/29 00:00 [accepted]
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - IA-DT# 20 [pii]
AID - 10.2174/187152810792231913 [doi]
PST - ppublish
SO  - Inflamm Allergy Drug Targets. 2010 Jul;9(3):173-80. doi: 
      10.2174/187152810792231913.