PMID- 2055378
OWN - NLM
STAT- MEDLINE
DCOM- 19910726
LR  - 20131121
IS  - 0046-5968 (Print)
IS  - 0046-5968 (Linking)
VI  - 21
IP  - 1
DP  - 1991 Jan
TI  - Reduction of complex ventricular arrhythmias after enalapril treatment in 
      patients with advanced stable heart failure.
PG  - 59-65
AB  - We studied, by 48-hour Holter monitoring, 33 patients with chronic stable heart 
      failure (radionuclide ejection fraction less than 35%), complex ventricular 
      arrhythmias and no electrolyte abnormalities, after a period during which they 
      were treated with digoxin and diuretics. Before Holter monitoring blood samples 
      were analyzed for serum concentration of sodium, potassium, magnesium, urea, 
      creatinine, digoxin, aldosterone and for plasmatic renin activity in addition to 
      urinary aldosterone and catecholamines determination. After these investigations 
      in 23 patients, 5-20 mg of enalapril were progressively added to the conventional 
      therapy, while 10 patients continued the previous therapy. After 8 weeks 30 
      patients were subjected to a second 48-hour Holter monitoring and to the same 
      biochemical and hormonal tests. One patient died and 2 were lost to follow up. 
      Only the enalapril group showed a significant decrease in the number of premature 
      ventricular complexes (PVC) (p less than 0.01), and the frequency of couplets and 
      episodes of ventricular tachycardia (VT) declined significantly (P less than 
      0.01). In the two groups there were no significant changes in digoxin, sodium, or 
      magnesium, while potassium concentration increased in both groups (p less than 
      0.01). In the enalapril group heart rate and systolic and diastolic pressure 
      declined significantly (p less than 0.01), and New York Heart Association class 
      (NYHA) improved (p less than 0.001). In the other group there were no significant 
      changes in these parameters. Enalapril caused a significant increase in the 
      plasmatic renin activity (p less than 0.01) and a significant fall of plasma and 
      urinary aldosterone (p less than 0.01; p less than 0.05).(ABSTRACT TRUNCATED AT 
      250 WORDS)
FAU - Pomini, G
AU  - Pomini G
AD  - Servizio di Riabilitazione Cardiologica, Universita di Padova.
FAU - Gribaldo, R
AU  - Gribaldo R
FAU - Rugna, A
AU  - Rugna A
FAU - Lupia, M
AU  - Lupia M
FAU - Molfese, G
AU  - Molfese G
FAU - Carenza, P
AU  - Carenza P
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - G Ital Cardiol
JT  - Giornale italiano di cardiologia
JID - 1270331
RN  - 69PN84IO1A (Enalapril)
SB  - IM
MH  - Aged
MH  - Arrhythmias, Cardiac/complications/*drug therapy/physiopathology
MH  - Blood Pressure/drug effects
MH  - Chronic Disease
MH  - Electrocardiography, Ambulatory
MH  - Enalapril/*therapeutic use
MH  - Female
MH  - Heart Failure/*complications/physiopathology
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
PST - ppublish
SO  - G Ital Cardiol. 1991 Jan;21(1):59-65.