PMID- 20553852
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20100719
IS  - 1873-6300 (Electronic)
IS  - 0891-0618 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Oct
TI  - Maternal separation disrupts dendritic morphology of neurons in prefrontal 
      cortex, hippocampus, and nucleus accumbens in male rat offspring.
PG  - 93-101
LID - 10.1016/j.jchemneu.2010.05.005 [doi]
AB  - Neonatal maternal separation (MS) in rats has widely been used as a 
      neurodevelopmental model to mimic mood-related disorders. MS produces a wide 
      array of behavioral deficits that persist throughout adulthood. In this study we 
      investigate the effect of MS and substitute maternal handling (human handling) on 
      the dendritic morphology of neurons in the prefrontal cortex (PFC), the CA1 
      ventral hippocampus, and the nucleus accumbens (NAcc), brain regions in male rats 
      that have been associated with affective disorders at pre-pubertal (postnatal day 
      35 (PND35)) and post-pubertal (PND60) ages. The morphological characteristics of 
      dendrites were studied by using the Golgi-Cox staining method. MS induced 
      decreases in total dendritic length and dendritic spine density in the neurons of 
      the PFC, the CA1 ventral hippocampus, and the NAcc at a post-pubertal age. 
      Conversely, human handling produced an increase in dendritic spine density in the 
      pyramidal neurons of the PFC and the hippocampus at a pre-pubertal age, and a 
      decrease in the dendritic length of the NAcc neurons at a post-pubertal age. 
      These results suggest that the maternal care condition affects the dendritic 
      morphology of neurons in the PFC, the CA1 ventral hippocampus, and the NAcc at 
      different ages. These anatomical modifications may be relevant to altered 
      behaviors observed in maternally separated animals.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Monroy, Elibeth
AU  - Monroy E
AD  - Facultad de Medicina, Universidad Autonoma de Puebla, Mexico.
FAU - Hernandez-Torres, Elizabeth
AU  - Hernandez-Torres E
FAU - Flores, Gonzalo
AU  - Flores G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100527
PL  - Netherlands
TA  - J Chem Neuroanat
JT  - Journal of chemical neuroanatomy
JID - 8902615
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - *Cell Shape
MH  - *Dendrites
MH  - Dendritic Spines
MH  - Hippocampus/*cytology
MH  - Male
MH  - Maternal Deprivation
MH  - Motor Activity
MH  - Neurons/*cytology
MH  - Nucleus Accumbens/*cytology
MH  - Prefrontal Cortex/*cytology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Silver Staining
EDAT- 2010/06/18 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/06/18 06:00
PHST- 2009/08/31 00:00 [received]
PHST- 2010/05/17 00:00 [revised]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - S0891-0618(10)00074-8 [pii]
AID - 10.1016/j.jchemneu.2010.05.005 [doi]
PST - ppublish
SO  - J Chem Neuroanat. 2010 Oct;40(2):93-101. doi: 10.1016/j.jchemneu.2010.05.005. 
      Epub 2010 May 27.