PMID- 20554288
OWN - NLM
STAT- MEDLINE
DCOM- 20100917
LR  - 20131121
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1217
IP  - 30
DP  - 2010 Jul 23
TI  - Separation of chiral primary amino compounds by forming a sandwiched complex in 
      reversed-phase high performance liquid chromatography.
PG  - 4965-70
LID - 10.1016/j.chroma.2010.05.053 [doi]
AB  - Separation of chiral primary amino compounds was efficiently achieved under 
      reversed-phase high performance liquid chromatography (RP-HPLC) conditions using 
      a mixture of non-chiral crown ether (18-crown-6) and dimethyl-beta-cyclodextrin 
      (DM-beta-CD) in the mobile phase. Under these conditions, the amino group of the 
      chiral compound was protonated in a low pH mobile phase, and then interacted with 
      18-crown-6 and DM-beta-CD to form a sandwiched complex [18-crown-6+amine+CD]. 
      Enantiomers of the compound in the sandwiched complex were separated with good 
      enantioselectivity. Formation of the sandwiched complex among the chiral compound 
      and additives in the mobile phase is a key step of the chiral separation. Four 
      different chiral amino compounds namely, 1-aminoindan (AI), 
      1,2,3,4-tetrahydro-1-naphthylamine (THNA), tyrosine (Tyr), and phenylalanine 
      (Phe), were selected to demonstrate the separation using the sandwiched complex 
      mechanism in RP-HPLC.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Zhang, Chen
AU  - Zhang C
AD  - Global Quality Services-Analytical Science, Schering-Plough Corp., 1011 Morris 
      Avenue, Union, NJ 07083, USA.
FAU - Huang, Wei X
AU  - Huang WX
FAU - Chen, Zhi
AU  - Chen Z
FAU - Rustum, Abu M
AU  - Rustum AM
LA  - eng
PT  - Journal Article
DEP - 20100602
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Amino Acids)
RN  - 0 (Indans)
RN  - 34698-41-4 (1-aminoindan)
RN  - 9753I242R5 (1-Naphthylamine)
SB  - IM
MH  - 1-Naphthylamine/*chemistry
MH  - Amino Acids/*chemistry
MH  - Chromatography, Reverse-Phase/*instrumentation/*methods
MH  - Indans/*chemistry
MH  - Stereoisomerism
EDAT- 2010/06/18 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/02/08 00:00 [received]
PHST- 2010/05/21 00:00 [revised]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - S0021-9673(10)00725-9 [pii]
AID - 10.1016/j.chroma.2010.05.053 [doi]
PST - ppublish
SO  - J Chromatogr A. 2010 Jul 23;1217(30):4965-70. doi: 10.1016/j.chroma.2010.05.053. 
      Epub 2010 Jun 2.