PMID- 20556351
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20211020
IS  - 1432-1440 (Electronic)
IS  - 0946-2716 (Linking)
VI  - 88
IP  - 9
DP  - 2010 Sep
TI  - Regulation of antigen uptake, migration, and lifespan of dendritic cell by 
      Toll-like receptors.
PG  - 873-80
LID - 10.1007/s00109-010-0638-x [doi]
AB  - Dendritic cells (DCs) sense the presence of pathogens through germline-encoded 
      pattern recognition receptors (PRRs), which recognize molecular patterns 
      expressed by various microorganisms and endogenous stimuli. Toll-like receptors 
      (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a 
      number of DC activities, including endocytosis, cytoskeleton rearrangement, 
      migration, antigen processing and presentation, survival, and death. The goal of 
      TLR-induced DC reprogramming is to promote the appropriate activation and 
      differentiation of lymphocytes bearing clonally distributed antigen-specific 
      receptors. In this review, we will focus on the functional consequences of TLR 
      engagement for conventional DCs.
FAU - Zanoni, Ivan
AU  - Zanoni I
AD  - Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza 
      della Scienza 2, 20126 Milan, Italy.
FAU - Granucci, Francesca
AU  - Granucci F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100618
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 0 (Antigens)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - *Antigen Presentation
MH  - Antigens/immunology/metabolism
MH  - Cell Death
MH  - Cell Movement
MH  - Cell Survival/physiology
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Models, Biological
MH  - Toll-Like Receptors/*metabolism
EDAT- 2010/06/18 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/01/22 00:00 [received]
PHST- 2010/05/25 00:00 [accepted]
PHST- 2010/05/11 00:00 [revised]
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.1007/s00109-010-0638-x [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2010 Sep;88(9):873-80. doi: 10.1007/s00109-010-0638-x. Epub 
      2010 Jun 18.