PMID- 20556444
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20211020
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 118
IP  - 3
DP  - 2011 Mar
TI  - The link between iron, metabolic syndrome, and Alzheimer's disease.
PG  - 371-9
LID - 10.1007/s00702-010-0426-3 [doi]
AB  - Both Alzheimer's disease (AD), the most common form of dementia, and type-2 
      diabetes mellitus (T2DM), a disease associated with metabolic syndrome (MetS), 
      affect a great number of the world population and both have increased prevalence 
      with age. Recently, many studies demonstrated that pre-diabetes, MetS, and T2DM 
      are risk factors in the development of AD and have many common mechanisms. The 
      main focus of studies is the insulin resistance outcome found both in MetS as 
      well as in brains of AD subjects. However, oxidative stress (OS)-related 
      mechanisms, which are well known to be involved in AD, including mitochondrial 
      dysfunction, elevated iron concentration, reactive oxygen species (ROS), and 
      stress-related enzyme or proteins (e.g. heme oxygenase-1, transferrin, etc.), 
      have not been elucidated in MetS or T2DM brains although OS and iron are involved 
      in the degeneration of the pancreatic islet beta cells. Therefore, this review sets 
      to cover the current literature regarding OS and iron in MetS and T2DM and the 
      similarities to mechanisms in AD both in human subjects as well as in animal 
      models.
FAU - Grunblatt, Edna
AU  - Grunblatt E
AD  - Department of Child and Adolescent Psychiatry, University of Zurich, 
      Neumuensterallee 9, 8032, Zurich, Switzerland. 
      Gruenblatt_E@klinik.uni-wuerzburg.de
FAU - Bartl, Jasmin
AU  - Bartl J
FAU - Riederer, Peter
AU  - Riederer P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100617
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Reactive Oxygen Species)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Alzheimer Disease/*metabolism
MH  - Brain/metabolism
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Heme Oxygenase-1/metabolism
MH  - Humans
MH  - Iron/*metabolism
MH  - Metabolic Syndrome/*metabolism
MH  - Oxidative Stress/physiology
MH  - Reactive Oxygen Species/metabolism
EDAT- 2010/06/18 06:00
MHDA- 2011/08/17 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/04/22 00:00 [received]
PHST- 2010/05/22 00:00 [accepted]
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 10.1007/s00702-010-0426-3 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2011 Mar;118(3):371-9. doi: 10.1007/s00702-010-0426-3. 
      Epub 2010 Jun 17.