PMID- 20556784
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20211028
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
IP  - 6
DP  - 2010 Jun 16
TI  - Anticoagulant therapy for deep vein thrombosis (DVT) in pregnancy.
PG  - CD007801
LID - 10.1002/14651858.CD007801.pub2 [doi]
AB  - BACKGROUND: Thromboembolic complications are much higher in pregnancy due to 
      procoagulant changes. Heparin does not cross the placenta and the use of 
      unfractionated heparin (UFH) is the current established practice in prophylaxis 
      and treatment for thromboembolism in pregnancy. OBJECTIVES: To compare the 
      effectiveness of anticoagulant therapies for the treatment of deep vein 
      thrombosis in pregnancy. The anticoagulant drugs included are UFH, low molecular 
      weight heparin (LMWH) and warfarin. SEARCH STRATEGY: We searched the Cochrane 
      Pregnancy and Childbirth Group's Trials Register (March 2010) and reference lists 
      of retrieved studies. SELECTION CRITERIA: Randomised controlled trials comparing 
      any combination of warfarin, UFH, LMWH and placebo in pregnant women. DATA 
      COLLECTION AND ANALYSIS: We used methods described in the Cochrane Handbooks for 
      Systemic Reviews of Interventions for assessing the eligibility of studies 
      identified by the search strategy. A minimum of two review authors independently 
      assessed each study. MAIN RESULTS: We did not identify any eligible studies for 
      inclusion in the review.We identified three potential studies; after assessing 
      eligibility, we excluded all three as they did not meet the prespecified 
      inclusion criteria. One study compared LMWH and UFH in pregnant women with 
      previous thromboembolic events and, for most of these women, anticoagulants were 
      used as thromboprophylaxis. There were only three women who had a thromboembolic 
      event during the current pregnancy and it was unclear whether the anticoagulant 
      was used as therapy or prophylaxis. We excluded one study because it included 
      only women undergoing caesarean birth. The third study was not a randomised 
      trial. AUTHORS' CONCLUSIONS: There is no evidence from randomised controlled 
      trials on the effectiveness of anticoagulation for deep vein thrombosis in 
      pregnancy. Further studies are required.
FAU - Che Yaakob, Che Anuar
AU  - Che Yaakob CA
AD  - Department of Obstetrics and Gynaecology, Universiti Sains Malaysia, School of 
      Medical Sciences, Health Campus, Kubang Kerian, Kelantan, Malaysia, 16150.
FAU - Dzarr, Abdulla Abu
AU  - Dzarr AA
FAU - Ismail, Ahmad Amir
AU  - Ismail AA
FAU - Zuky Nik Lah, Nik Ahmad
AU  - Zuky Nik Lah NA
FAU - Ho, Jacqueline J
AU  - Ho JJ
LA  - eng
GR  - 071672/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20100616
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 5Q7ZVV76EI (Warfarin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/*therapeutic use
MH  - Female
MH  - Heparin/therapeutic use
MH  - Heparin, Low-Molecular-Weight/therapeutic use
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/*drug therapy
MH  - Venous Thrombosis/*drug therapy
MH  - Warfarin/therapeutic use
PMC - PMC4238056
MID - EMS58191
OID - NLM: EMS58191
EDAT- 2010/06/18 06:00
MHDA- 2010/07/28 06:00
PMCR- 2014/11/20
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
PHST- 2014/11/20 00:00 [pmc-release]
AID - 10.1002/14651858.CD007801.pub2 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2010 Jun 16;(6):CD007801. doi: 
      10.1002/14651858.CD007801.pub2.