PMID- 20557576
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20231213
IS  - 1468-2494 (Electronic)
IS  - 0142-5463 (Linking)
VI  - 32
IP  - 3
DP  - 2010 Jun
TI  - Microencapsulation of rosmarinic acid using polycaprolactone and various 
      surfactants.
PG  - 185-91
LID - 10.1111/j.1468-2494.2010.00526.x [doi]
AB  - Rosmarinic acid (RA) has a number of interesting biological activities, e.g. 
      anti-viral, anti-bacterial, anti-inflammatory and antioxidant. The antioxidant 
      activity of RA is stronger than that of vitamin E. Despite its strong antioxidant 
      activity, it was limited to use in cosmetics because of the low water solubility, 
      discolouration and chemical instability. The purpose of this study was to prepare 
      RA-loaded polycaprolactone (PCL) microspheres using emulsion solvent evaporation 
      method and characterize them with different surfactants used in the formation 
      process. Finally, long-term stability of RA was evaluated in the cosmetic 
      formulation. As a result, PCL microspheres were found to be spherical in shape, 
      with zwitterionic surfactant-PCL particles being the smallest size distribution 
      and highest entrapment efficiency of RA. Emulsions containing RA-loaded PCL 
      microspheres showed a better long-term stability of the RA compared with those 
      containing only RA. These results suggest that RA may be stably and efficiently 
      encapsulated into polycaprolactone microspheres.
FAU - Kim, H-J
AU  - Kim HJ
AD  - HANBUL COSMETICS Co. Ltd., R & D Center, Umsung-Kun, Chung-Buk, Korea. 
      heroisdead@empal.com
FAU - Kim, T-H
AU  - Kim TH
FAU - Kang, K-C
AU  - Kang KC
FAU - Pyo, H-B
AU  - Pyo HB
FAU - Jeong, H-H
AU  - Jeong HH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Cosmet Sci
JT  - International journal of cosmetic science
JID - 8007161
RN  - 0 (Antioxidants)
RN  - 0 (Cinnamates)
RN  - 0 (Depsides)
RN  - 0 (Polyesters)
RN  - 0 (Surface-Active Agents)
RN  - 24980-41-4 (polycaprolactone)
SB  - IM
MH  - Antioxidants/chemistry
MH  - Cinnamates/*chemistry
MH  - Depsides/*chemistry
MH  - Drug Compounding
MH  - Microscopy, Electron, Scanning
MH  - Microspheres
MH  - Polyesters/*chemistry
MH  - Surface-Active Agents/*chemistry
MH  - Rosmarinic Acid
EDAT- 2010/06/19 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - ICS526 [pii]
AID - 10.1111/j.1468-2494.2010.00526.x [doi]
PST - ppublish
SO  - Int J Cosmet Sci. 2010 Jun;32(3):185-91. doi: 10.1111/j.1468-2494.2010.00526.x.