PMID- 20557944
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20220318
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 117
IP  - 11
DP  - 2010 Nov
TI  - Outer retinal hyperreflective spots on spectral-domain optical coherence 
      tomography in macular telangiectasia type 2.
PG  - 2162-8
LID - 10.1016/j.ophtha.2010.02.014 [doi]
AB  - PURPOSE: To analyze focal hyperreflective morphologic alterations in outer 
      retinal layers in patients with type 2 idiopathic macular telangiectasia (MacTel 
      type 2) using spectral-domain optical coherence tomography (SD OCT). DESIGN: 
      Cross-sectional case-control study. PARTICIPANTS: Forty-one patients with MacTel 
      type 2. METHODS: Anatomic layers were evaluated and compared with those of 
      controls of similar age. Simultaneous SD OCT scans were obtained with a combined 
      confocal scanning laser ophthalmoscope for simultaneous tomographic and 
      topographic in vivo imaging (Spectralis HRA+OCT; Heidelberg Engineering, 
      Heidelberg, Germany). MAIN OUTCOME MEASURES: Morphologic alterations in the 
      retinal layers secondary to MacTel type 2. RESULTS: Hyperreflective spots in the 
      outer retina of MacTel type 2 patients were detected in all stages of disease 
      using the SD OCT. Their presence was confined to the foveolar and parafoveolar 
      region. The phenomenon also was detected in a monozygotic twin in an eye with no 
      typical angiographic sign of the disease. A hyperreflective haze was detected in 
      the vicinity of a disruption of the hyperreflective OCT line that is assumed to 
      represent the line between the photoreceptor inner and outer segments and 
      interdigitation of the outer segments and the retinal pigment epithelium. No 
      corresponding pathologic features could be identified by biomicroscopy, 
      time-domain OCT, or confocal scanning laser ophthalmoscope imaging. Crystalline 
      deposits and intraretinal migration of pigmented cells were distinguishable 
      because of differences in shape, reflectivity, and location. CONCLUSIONS: 
      Hyperreflective spots were identified in outer retinal layers of patients with 
      MacTel type 2 in all disease stages. It is suggested that this phenomenon 
      represents an early sign of a neurodegenerative process. Secondary assumptions 
      include extravasated deposits or vascular abnormalities. The pathologic features 
      are indicative of an active disease process before the disease manifests by 
      typical fluorescein angiographic signs. FINANCIAL DISCLOSURE(S): Proprietary or 
      commercial disclosure may be found after the references.
CI  - Copyright (c) 2010 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Baumuller, Sonke
AU  - Baumuller S
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Charbel Issa, Peter
AU  - Charbel Issa P
FAU - Scholl, Hendrik P N
AU  - Scholl HP
FAU - Schmitz-Valckenberg, Steffen
AU  - Schmitz-Valckenberg S
FAU - Holz, Frank G
AU  - Holz FG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100616
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ophthalmoscopy
MH  - Retina/*pathology
MH  - Retinal Diseases/*diagnosis
MH  - Retinal Vessels/*pathology
MH  - Telangiectasis/*diagnosis
MH  - *Tomography, Optical Coherence
EDAT- 2010/06/19 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/06/19 06:00
PHST- 2009/09/04 00:00 [received]
PHST- 2010/02/06 00:00 [revised]
PHST- 2010/02/11 00:00 [accepted]
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - S0161-6420(10)00178-8 [pii]
AID - 10.1016/j.ophtha.2010.02.014 [doi]
PST - ppublish
SO  - Ophthalmology. 2010 Nov;117(11):2162-8. doi: 10.1016/j.ophtha.2010.02.014. Epub 
      2010 Jun 16.