PMID- 20559009
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20111117
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 153
IP  - 4
DP  - 2010
TI  - HLA status in patients with chronic spontaneous urticaria.
PG  - 419-23
LID - 10.1159/000316354 [doi]
AB  - Chronic spontaneous urticaria (CSU) is the most common form of chronic urticaria. 
      A considerable amount of data supports an immunological basis for CSU. Some 
      research has focused on the association between chronic urticaria and specific 
      human leukocyte antigen (HLA) alleles. The aim of this study was to investigate 
      the HLA status of Polish patients diagnosed with CSU. METHODS: The standard 
      complement-dependent microlymphocytotoxicity assay and PCR amplification with 
      sequence-specific primers were used to analyze HLA alleles in 115 patients 
      diagnosed with CSU, and the results were compared to those from 162 healthy, 
      genetically unrelated individuals. RESULTS: Among the HLA-A alleles, A-33 
      occurred significantly more often in the control group (p < 0.01). Analysis of 
      the HLA-B allele frequencies revealed the prevalence of the B44 antigen in the 
      study group (p < 0.0001). Frequencies of HLA-C alleles and HLA-DQ did not differ 
      significantly between the groups. Among the HLA class II alleles, DRB1*04 was 
      observed significantly more often in the study population (p < 0.001), mainly in 
      the autoimmunological subtype of urticaria. CONCLUSION: HLA alleles may be 
      involved in CSU development or play a protective role in CSU.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Bozek, Andrzej
AU  - Bozek A
AD  - Clinical Department of Internal Medicine, Dermatology and Allergology, Medical 
      University of Silesia, Zabrze, Poland. andrzejbozek@o2.pl
FAU - Krajewska, Jolanta
AU  - Krajewska J
FAU - Filipowska, Barbara
AU  - Filipowska B
FAU - Polanska, Jolanta
AU  - Polanska J
FAU - Rachowska, Regina
AU  - Rachowska R
FAU - Grzanka, Alicja
AU  - Grzanka A
FAU - Jarzab, Jerzy
AU  - Jarzab J
LA  - eng
PT  - Journal Article
DEP - 20100618
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*33 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B44 Antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-A Antigens/genetics/immunology/*metabolism
MH  - HLA-B Antigens/genetics/immunology/*metabolism
MH  - HLA-B44 Antigen
MH  - HLA-DR Antigens/genetics/immunology/*metabolism
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Poland
MH  - Polymorphism, Genetic
MH  - Urticaria/*genetics/*immunology
EDAT- 2010/06/19 06:00
MHDA- 2011/03/09 06:00
CRDT- 2010/06/19 06:00
PHST- 2009/05/21 00:00 [received]
PHST- 2010/02/01 00:00 [accepted]
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 000316354 [pii]
AID - 10.1159/000316354 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2010;153(4):419-23. doi: 10.1159/000316354. Epub 2010 
      Jun 18.