PMID- 20559070
OWN - NLM
STAT- MEDLINE
DCOM- 20130815
LR  - 20100618
IS  - 1524-4040 (Electronic)
IS  - 0148-396X (Linking)
VI  - 67
IP  - 1
DP  - 2010 Jul
TI  - Anaplastic meningioma arising from a radiologically diagnosed arachnoid cyst: 
      case report.
PG  - 212-3
LID - 10.1227/01.NEU.0000370013.55369.92 [doi]
AB  - OBJECTIVE AND IMPORTANCE: We report the first example of an anaplastic meningioma 
      arising from an intracranial arachnoid cyst and discuss the diagnostic challenges 
      of this case, including the useful role of genetic markers. CLINICAL 
      PRESENTATION: A 72-year-old man presented with transient episodes of expressive 
      dysphasia and focal motor seizures, superimposed on a 6-month history of 
      worsening headaches and dizziness. His past history was significant for a 
      previously drained left-sided chronic subdural hematoma and a radiologically 
      diagnosed left middle fossa arachnoid cyst. Magnetic resonance imaging on 
      admission showed variable wall thickening of the arachnoid cyst with mild mass 
      effect on the left frontotemporal lobes. INTERVENTION: The patient underwent 
      decompression of the arachnoid cyst and biopsy of the cyst wall. Histologic and 
      immunohistochemical studies of the thickened portion initially suggested a 
      metastatic carcinosarcoma, but fluorescence in situ hybridization (FISH) studies 
      confirmed the diagnosis of anaplastic meningioma based on characteristic 
      chromosomal deletions. The patient returned 2 months later with progressive 
      disease, leading to his death 6 weeks later despite repeat surgery for tumor 
      debulking. CONCLUSION: Malignant transformation of meningothelial elements in 
      arachnoid cysts is an exceptionally rare complication that poses considerable 
      diagnostic challenges. Genetic markers may be particularly helpful in such cases.
FAU - Lwu, Shelly
AU  - Lwu S
AD  - Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, 
      Canada (Lwu) (Starreveld) Department of Pathology and Immunology, Washington 
      University School of Medicine, St. Louis, Missouri (Branson) (Perry).
FAU - Starreveld, Yves Pieter
AU  - Starreveld YP
FAU - Branson, Julie
AU  - Branson J
FAU - Perry, Arie
AU  - Perry A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Neurosurgery
JT  - Neurosurgery
JID - 7802914
SB  - IM
MH  - Aged
MH  - Aphasia, Broca/etiology
MH  - Arachnoid Cysts/*complications/*pathology/physiopathology
MH  - Fatal Outcome
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Meningeal Neoplasms/*etiology/*pathology/surgery
MH  - Meningioma/*etiology/*pathology/surgery
MH  - Reoperation
EDAT- 2010/06/19 06:00
MHDA- 2013/08/16 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2013/08/16 06:00 [medline]
AID - 00006123-201007000-00032 [pii]
AID - 10.1227/01.NEU.0000370013.55369.92 [doi]
PST - ppublish
SO  - Neurosurgery. 2010 Jul;67(1):212-3. doi: 10.1227/01.NEU.0000370013.55369.92.