PMID- 2055914
OWN - NLM
STAT- MEDLINE
DCOM- 19910731
LR  - 20131121
IS  - 0021-9304 (Print)
IS  - 0021-9304 (Linking)
VI  - 25
IP  - 2
DP  - 1991 Feb
TI  - Fibroblast stimulation by monocytes cultured on protein adsorbed biomedical 
      polymers. I. Biomer and polydimethylsiloxane.
PG  - 165-75
AB  - The studies presented in this paper evaluate the modulatory role of protein 
      pre-adsorbed polydimethylsiloxane (PDMS) and Biomer on the secretion of 
      fibroblast stimulating growth factors from human monocytes/macrophages. The 
      results of these studies show that Biomer and PDMS selectively activate human 
      monocytes to produce fibroblast "progression-like" and to a lesser extent 
      "competence-like" stimulating growth factors. Polydimethylsiloxane stimulated the 
      monocytes/macrophages to produce more "progression-like" fibro-blast stimulating 
      growth factors than Biomer. The induction of "competence-like" fibroblast 
      stimulating activity from the monocytes was enhanced by preadsorption of PDMS 
      with human derived fibrinogen, fibronectin, IgG, hemoglobin, or albumin. This 
      phenomenon was not observed with protein pre-adsorbed Biomer. These studies 
      support the hypothesis that protein pre-adsorbed polymers will selectively 
      modulate monocyte/macrophage activation and induction of growth factors which 
      have the potential to participate in tissue-implant interactions in vivo.
FAU - Bonfield, T L
AU  - Bonfield TL
AD  - Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
FAU - Colton, E
AU  - Colton E
FAU - Anderson, J M
AU  - Anderson JM
LA  - eng
GR  - HL-25239/HL/NHLBI NIH HHS/United States
GR  - HL-27277/HL/NHLBI NIH HHS/United States
GR  - HL-33849/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biomed Mater Res
JT  - Journal of biomedical materials research
JID - 0112726
RN  - 0 (Biocompatible Materials)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Growth Substances)
RN  - 0 (Polyurethanes)
RN  - 0 (Silicones)
RN  - 61789-63-7 (biomer)
RN  - 63148-62-9 (baysilon)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Adult
MH  - Biocompatible Materials
MH  - Cell Communication
MH  - Cell Division
MH  - Cell Survival
MH  - Cells, Cultured
MH  - DNA Replication
MH  - Dimethylpolysiloxanes
MH  - Fetus
MH  - Fibroblasts/cytology/physiology
MH  - Growth Substances/biosynthesis
MH  - Humans
MH  - Kinetics
MH  - Leukocytes, Mononuclear/cytology/*physiology
MH  - Polyurethanes
MH  - Silicones
MH  - Thymidine/metabolism
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
AID - 10.1002/jbm.820250204 [doi]
PST - ppublish
SO  - J Biomed Mater Res. 1991 Feb;25(2):165-75. doi: 10.1002/jbm.820250204.