PMID- 20560100
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20100618
IS  - 1439-3999 (Electronic)
IS  - 0023-2165 (Linking)
VI  - 227
IP  - 6
DP  - 2010 Jun
TI  - [Visual acuity following Descemet-membrane endothelial keratoplasty (DMEK): first 
      100 cases operated on for Fuchs endothelial dystrophy].
PG  - 467-77
LID - 10.1055/s-0029-1245446 [doi]
AB  - PURPOSE: The aim of this study was to evaluate the visual outcome and endothelial 
      cell density in the first series of 100 eyes after Descemet membrane endothelial 
      keratoplasty (DMEK) for the treatment of Fuchs endothelial dystrophy. DESIGN: 
      This was a non-randomised prospective clinical trial. METHODS: The first 100 
      consecutive eyes (87 patients) that underwent DMEK (i. e., transplantation of an 
      isolated donor Descemet membrane carrying its endothelium) for Fuchs endothelial 
      dystrophy were evaluated. In all eyes, the best corrected visual acuity (BCVA) as 
      well as the endothelial cell density (ECD) were measured before and at one, three 
      and six months after surgery. RESULTS: In eyes with a functional DMEK graft and 
      good visual potential (n = 78), the BCVA was > or = 20 / 40 (> or = 0.5) in 79 % 
      after 1 month, 94 % after 3 months, and 96 % after six months; > or = 20 / 25 (> 
      or = 0.8) in respectively 54 %, 64 %, and 74 %, and > or = 20 / 20 (> or = 1.0) 
      in respectively 26 %, 36 %, and 45 %. In this group, ECD averaged 2630 (+/- 190) 
      cells/mm (2) before, and 1800 (+/- 540) cells/mm (2) at six months after surgery 
      (n = 76). In 15 eyes, a secondary "Descemet stripping endothelial keratoplasty" 
      (DSEK) was performed. When the outcomes of DMEK and secondary DSEK procedures 
      were combined, 91 % reached a BCVA of > or = 20 / 40 (> or = 0.5), 65 % > or = 20 
      / 25 (> or = 0.8) and 38 % > or = 20 / 25 (> or = 1.0) at six months after 
      surgery (n = 93). For the whole group, ECD averaged 2620 (+/- 190) cells/mm (2) 
      before, and 1730 (+/- 590) cells/mm (2) at six months after surgery (n = 89). 
      CONCLUSION: DMEK may provide relatively quick and nearly complete visual 
      rehabilitation in a majority of patients operated on for Fuchs endothelial 
      dystrophy. Endothelial cell survival may be similar to earlier types of 
      endothelial keratoplasty. Early graft detachment (19 cases) was the main 
      complication in this first series of DMEK surgeries.
CI  - Georg Thieme Verlag KG Stuttgart, New York.
FAU - Droutsas, K
AU  - Droutsas K
AD  - NIIOS, Niederlandisches Institut fur Innovative Augenchirurgie, Rotterdam.
FAU - Ham, L
AU  - Ham L
FAU - Dapena, I
AU  - Dapena I
FAU - Geerling, G
AU  - Geerling G
FAU - Oellerich, S
AU  - Oellerich S
FAU - Melles, G
AU  - Melles G
LA  - ger
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Visus nach Descemet-Membran Endothelkeratoplastik (DMEK): Ergebnisse der ersten 
      100 Eingriffe bei Fuchs'scher Endotheldystrophie.
DEP - 20100617
PL  - Germany
TA  - Klin Monbl Augenheilkd
JT  - Klinische Monatsblatter fur Augenheilkunde
JID - 0014133
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Descemet Stripping Endothelial Keratoplasty/*methods
MH  - Female
MH  - Fuchs' Endothelial Dystrophy/complications/*diagnosis/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Treatment Outcome
MH  - Vision, Low/*diagnosis/etiology/*surgery
MH  - *Visual Acuity
EDAT- 2010/06/19 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - 10.1055/s-0029-1245446 [doi]
PST - ppublish
SO  - Klin Monbl Augenheilkd. 2010 Jun;227(6):467-77. doi: 10.1055/s-0029-1245446. Epub 
      2010 Jun 17.