PMID- 2056055
OWN - NLM
STAT- MEDLINE
DCOM- 19910801
LR  - 20210526
IS  - 0095-1137 (Print)
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Linking)
VI  - 29
IP  - 5
DP  - 1991 May
TI  - Evaluation of a solid-phase immunoassay for the simultaneous detection of 
      antibodies to human immunodeficiency virus type 1 and human T-cell lymphotropic 
      virus type I.
PG  - 897-900
AB  - We describe the evaluation of a solid-phase immunoassay developed for the 
      simultaneous detection of antibodies to human immunodeficiency virus type 1 
      (HIV-1) and human T-cell lymphotropic virus types I (HTLV-I) and II (HTLV-II) in 
      human serum. The immunoassay employs a mixture of HIV-1 and HTLV-I whole viral 
      lysates immobilized in the wells of microtiter plates. Evaluation of genetically 
      well-pedigreed specimens along with normal blood donor samples indicated that the 
      performance characteristics of the test were equivalent to the sensitivity and 
      specificity of individual tests licensed by the Food and Drug Administration for 
      antibodies to HIV-1 and HTLV-I. Furthermore, the test was also able to detect the 
      presence of cross-reacting antibodies in HTLV-II-infected individuals. The use of 
      such a test would greatly reduce the continually mounting costs associated with 
      screening transfusable products for infectious agents.
FAU - Montagna, R A
AU  - Montagna RA
AD  - Cellular Products, Inc., Buffalo, New York 14202.
FAU - Papsidero, L
AU  - Papsidero L
FAU - Poiesz, B J
AU  - Poiesz BJ
LA  - eng
GR  - N01 HB67021/HB/NHLBI NIH HHS/United States
GR  - R01 HL 43602-01/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
RN  - 0 (HIV Antibodies)
RN  - 0 (HTLV-I Antibodies)
RN  - 0 (HTLV-II Antibodies)
SB  - IM
MH  - Enzyme-Linked Immunosorbent Assay/*methods
MH  - Evaluation Studies as Topic
MH  - HIV Antibodies/*blood
MH  - HIV-1/*immunology
MH  - HTLV-I Antibodies/*blood
MH  - HTLV-II Antibodies/blood
MH  - Humans
MH  - Sensitivity and Specificity
PMC - PMC269904
EDAT- 1991/05/01 00:00
MHDA- 1991/05/01 00:01
PMCR- 1991/05/01
CRDT- 1991/05/01 00:00
PHST- 1991/05/01 00:00 [pubmed]
PHST- 1991/05/01 00:01 [medline]
PHST- 1991/05/01 00:00 [entrez]
PHST- 1991/05/01 00:00 [pmc-release]
AID - 10.1128/jcm.29.5.897-900.1991 [doi]
PST - ppublish
SO  - J Clin Microbiol. 1991 May;29(5):897-900. doi: 10.1128/jcm.29.5.897-900.1991.