PMID- 20561987
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20211020
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 584
IP  - 14
DP  - 2010 Jul 16
TI  - MCP-induced protein 1 suppresses TNFalpha-induced VCAM-1 expression in human 
      endothelial cells.
PG  - 3065-72
LID - 10.1016/j.febslet.2010.05.040 [doi]
AB  - Endothelial inflammation plays a critical role in the development and progression 
      of cardiovascular disease, albeit the mechanisms need to be fully elucidated. We 
      here report that treatment of human umbilical vein endothelial cells (HUVECs) 
      with tumor necrosis factor (TNF) alpha substantially increased the expression of 
      MCP-induced protein 1 (MCPIP1). Overexpression of MCPIP1 protected ECs against 
      TNFalpha-induced endothelial activation, as characterized by the attenuation in 
      the expression of the adhesion molecule VCAM-1 and monocyte adherence to ECs. 
      Conversely, small interfering RNA-mediated knock down of MCPIP1 increased the 
      expression of VCAM-1 and monocytic adherence to ECs. These studies identified 
      MCPIP1 as a feedback control of cytokines-induced endothelial inflammation.
CI  - Copyright 2010 Federation of European Biochemical Societies. Published by 
      Elsevier B.V. All rights reserved.
FAU - Qi, Yongfen
AU  - Qi Y
AD  - Burnett School of Biomedical Sciences, College of Medicine, University of Central 
      Florida, Orlando, FL 32816, USA.
FAU - Liang, Jian
AU  - Liang J
FAU - She, Zhi-Gang
AU  - She ZG
FAU - Cai, Yan
AU  - Cai Y
FAU - Wang, Jing
AU  - Wang J
FAU - Lei, Tianhua
AU  - Lei T
FAU - Stallcup, William B
AU  - Stallcup WB
FAU - Fu, Mingui
AU  - Fu M
LA  - eng
GR  - R01 CA095287/CA/NCI NIH HHS/United States
GR  - R21 HL098794/HL/NHLBI NIH HHS/United States
GR  - R21 HL098794-01A1/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100524
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - EC 1.14.13.39 (NOS3 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
SB  - IM
MH  - Cell Adhesion Molecules/*biosynthesis/immunology/*metabolism
MH  - Cytokines/immunology/metabolism/pharmacology
MH  - Endothelial Cells/cytology/immunology/metabolism
MH  - Endothelium/immunology/metabolism
MH  - Humans
MH  - Inflammation/immunology/metabolism
MH  - Monocytes/cytology/metabolism/physiology
MH  - Nitric Oxide Synthase Type III
MH  - Proteins/immunology/metabolism
MH  - Tumor Necrosis Factor-alpha/immunology/metabolism/*pharmacology
MH  - Umbilical Veins/cytology/immunology/metabolism
MH  - Vascular Cell Adhesion Molecule-1/*biosynthesis/genetics/*metabolism
PMC - PMC3587133
MID - NIHMS337509
EDAT- 2010/06/22 06:00
MHDA- 2010/07/28 06:00
PMCR- 2013/03/04
CRDT- 2010/06/22 06:00
PHST- 2010/04/08 00:00 [received]
PHST- 2010/05/11 00:00 [revised]
PHST- 2010/05/18 00:00 [accepted]
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
PHST- 2013/03/04 00:00 [pmc-release]
AID - S0014-5793(10)00433-3 [pii]
AID - 10.1016/j.febslet.2010.05.040 [doi]
PST - ppublish
SO  - FEBS Lett. 2010 Jul 16;584(14):3065-72. doi: 10.1016/j.febslet.2010.05.040. Epub 
      2010 May 24.