PMID- 20562055
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20211020
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 118
IP  - 10
DP  - 2010 Oct
TI  - Allergy and sensitization during childhood associated with prenatal and 
      lactational exposure to marine pollutants.
PG  - 1429-33
LID - 10.1289/ehp.1002289 [doi]
AB  - BACKGROUND: Breast-feeding may affect the risk of developing allergy during 
      childhood and may also cause exposure to immunotoxicants, such as polychlorinated 
      biphenyls (PCBs), which are of concern as marine pollutants in the Faroe Islands 
      and the Arctic region. OBJECTIVES: The objective was to assess whether 
      sensitization and development of allergic disease is associated with duration of 
      breast-feeding and prenatal or postnatal exposures to PCBs and methylmercury. 
      METHODS: A cohort of 656 singleton births was formed in the Faroe Islands during 
      1999-2001. Duration of breast-feeding and history of asthma and atopic dermatitis 
      were recorded at clinical examinations at 5 and 7 years of age. PCB and mercury 
      concentrations were determined in blood samples obtained at parturition and at 
      follow-up. Serum from 464 children (71%) at 7 years of age was analyzed for total 
      immunoglobulin E (IgE) and grass-specific IgE. RESULTS: The total IgE 
      concentration in serum at 7 years of age was positively associated both with the 
      concomitant serum PCB concentration and with the duration of breast-feeding. 
      However, the effect only of the latter was substantially attenuated in a 
      multivariate analysis. A raised grass-specific IgE concentration compatible with 
      sensitization was positively associated with the duration of breast-feeding and 
      inversely associated with prenatal methylmercury exposure. However, a history of 
      asthma or atopic dermatitis was not associated with the duration of 
      breast-feeding, although children with atopic dermatitis had lower prenatal PCB 
      exposures than did nonallergic children. CONCLUSIONS: These findings suggest that 
      developmental exposure to immunotoxicants may both increase and decrease the risk 
      of allergic disease and that associations between breast-feeding and subsequent 
      allergic disease in children may, at least in part, reflect lactational exposure 
      to immunotoxic food contaminants.
FAU - Grandjean, Philippe
AU  - Grandjean P
AD  - Institute of Public Health, University of Southern Denmark, Odense, Denmark. 
      pgrand@hsph.harvard.edu
FAU - Poulsen, Lars K
AU  - Poulsen LK
FAU - Heilmann, Carsten
AU  - Heilmann C
FAU - Steuerwald, Ulrike
AU  - Steuerwald U
FAU - Weihe, Pal
AU  - Weihe P
LA  - eng
GR  - R01 ES012199/ES/NIEHS NIH HHS/United States
GR  - ES 12199/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100601
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Water Pollutants, Chemical)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Denmark
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - Hypersensitivity/blood/*etiology
MH  - Immunoglobulin E/blood
MH  - *Lactation
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Seawater/*chemistry
MH  - Water Pollutants, Chemical/*toxicity
PMC - PMC2957924
EDAT- 2010/06/22 06:00
MHDA- 2011/01/14 06:00
PMCR- 2010/10/01
CRDT- 2010/06/22 06:00
PHST- 2010/04/13 00:00 [received]
PHST- 2010/06/01 00:00 [accepted]
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
PHST- 2010/10/01 00:00 [pmc-release]
AID - ehp-118-1429 [pii]
AID - 10.1289/ehp.1002289 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2010 Oct;118(10):1429-33. doi: 10.1289/ehp.1002289. Epub 
      2010 Jun 1.