PMID- 20562579
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20100621
IS  - 1536-4828 (Electronic)
IS  - 0885-3177 (Linking)
VI  - 39
IP  - 5
DP  - 2010 Jul
TI  - Multiple endocrine neoplasia type 1 simultaneous with various types of 
      enteropancreatic endocrine tumors: one case report: lessons learned.
PG  - 680-3
LID - 10.1097/MPA.0b013e3181d36341 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant disorder 
      characterized by the development of parathyroid hyperplasia, pancreatic endocrine 
      tumors, pituitary adenomas, and adrenal adenomas. We reported 1 case of MEN 1 
      simultaneous with gastrinoma and insulinoma; meanwhile, insulinomas were ectopic 
      and recurrent. The genetic screening showed the mutation of 427del AT of the MEN 
      1 gene. Surgical removal is considered the treatment of choice, with limited 
      adverse effects and relatively low morbidity and mortality. She was treated by 
      means of several surgical strategies, resulting in improvement of the frequency 
      and severity of the hypoglycemic episodes and a better quality of life.
FAU - Zhou, Guangwen
AU  - Zhou G
AD  - Department of Surgery, RuijinHospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Wei, Yao
AU  - Wei Y
FAU - Chen, Xi
AU  - Chen X
FAU - Jiang, Xiaohua
AU  - Jiang X
FAU - Gu, Weiqiong
AU  - Gu W
FAU - Li, Xiaoying
AU  - Li X
FAU - Peng, Chenhong
AU  - Peng C
FAU - Ning, Guang
AU  - Ning G
FAU - Li, Hongwei
AU  - Li H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pancreas
JT  - Pancreas
JID - 8608542
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gastrinoma/genetics/*surgery
MH  - Humans
MH  - Insulinoma/genetics/*surgery
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*surgery
MH  - Mutation
MH  - Pancreatic Neoplasms/genetics/*surgery
MH  - Parathyroid Neoplasms/genetics/*surgery
MH  - Pituitary Neoplasms/genetics/*surgery
MH  - Proto-Oncogene Proteins/genetics
MH  - Quality of Life
MH  - Treatment Outcome
EDAT- 2010/06/22 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 00006676-201007000-00022 [pii]
AID - 10.1097/MPA.0b013e3181d36341 [doi]
PST - ppublish
SO  - Pancreas. 2010 Jul;39(5):680-3. doi: 10.1097/MPA.0b013e3181d36341.