PMID- 20563363
OWN - NLM
STAT- MEDLINE
DCOM- 20101108
LR  - 20171116
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Linking)
VI  - 31
IP  - 6
DP  - 2010 Jun
TI  - Do components of metabolic syndrome contribute to cardiac autonomic neuropathy in 
      non-diabetic patients?
PG  - 650-7
AB  - OBJECTIVE: To evaluate whether autonomic dysfunction exist in patients with 
      metabolic syndrome (MetS) to establish any association with components of MetS. 
      METHODS: From July 2008 to January 2009, 32 outpatients attending the University 
      Clinical Center, Zemun, Belgrade, Serbia, 15 with MetS, 17 with type 2 diabetes 
      mellitus (T2DM), and 15 control subjects were recruited for cross-sectional study 
      among adults. The study was completed at the University Clinical Center, 
      Bezanijska Kosa, and University Clinical Center, Dragisa Misovic, Belgrade, 
      Serbia. Inclusion criteria were the presence of MetS without T2DM, T2DM and 
      healthy controls, matched for age and gender. Exclusion criteria were 
      uncontrolled diabetes (glycosylated hemoglobin [HbA1c] higher than 9%), advanced 
      complications of diabetes (retinopathy, nephropathy, coronary heart disease, or 
      peripheral angiopathy). Besides anthropometric and metabolic parameters 
      cardiovascular autonomic reflex tests, ambulatory ECG monitoring, and blood 
      pressure monitoring for 24 hours was obtained. Power spectral analysis of heart 
      rate variability (HRV) was carried out by Fourier transformation. RESULTS: Mean 
      total power (TP) log-transformed (ln), very low frequency (VLF)ln power, and high 
      frequency (HF)ln power were significantly lower in T2DM patients, when compared 
      with controls, and only HFln power was significantly lower in the MetS group. The 
      average value of low frequency (LF)/HFln ratio was significantly higher in T2DM 
      and MetS, and significantly correlated with glucose level of the last one. 
      CONCLUSION: Disturbed HRV indices were present in patients with MetS before the 
      development of T2DM. With this in mind, improvement of glucose metabolism, as 
      well as early detection of cardiac autonomic dysfunction should be important.
FAU - Rasic-Milutinovic, Zorica R
AU  - Rasic-Milutinovic ZR
AD  - Department of Endocrinology, Zemun Clinical Hospital, 9 Vukova Street, Zemun 
      11080, Belgrade, Serbia. zoricar@eunet.rs
FAU - Milicevic, Dusan R
AU  - Milicevic DR
FAU - Milovanovic, Branislav D
AU  - Milovanovic BD
FAU - Perunicic-Pekovic, Gordana B
AU  - Perunicic-Pekovic GB
FAU - Pencic, Biljana D
AU  - Pencic BD
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/physiopathology
MH  - Diabetic Neuropathies/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*physiopathology
MH  - Middle Aged
EDAT- 2010/06/22 06:00
MHDA- 2010/11/09 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/11/09 06:00 [medline]
AID - 20102083' [pii]
PST - ppublish
SO  - Saudi Med J. 2010 Jun;31(6):650-7.