PMID- 20563564
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20160512
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 398
IP  - 3
DP  - 2010 Oct
TI  - Multiresidue method for the determination of 32 human and veterinary 
      pharmaceuticals in soil and sediment by pressurized-liquid extraction and 
      LC-MS/MS.
PG  - 1173-84
LID - 10.1007/s00216-010-3862-x [doi]
AB  - An analytical chemical method has been developed for the simultaneous 
      determination of 32 different pharmaceuticals in soils and sediments. The 
      pharmaceuticals cover a varity of different compound groups. Soil samples were 
      extracted with different solvents with the help of pressurized-liquid extraction 
      (PLE) followed by clean-up using a solid-phase extraction (SPE) procedure. The 
      purified extracts were analyzed by LC-MS/MS. The extraction method was evaluated 
      by testing the following variables: extraction solvents, solvent pH, and 
      temperature. Applying 20 g of soil/sediment and extracting with a mixture of 
      methanol with aqueous ammonia solution (0.1 mol L(-1)) at 80 degrees C for 5 min 
      in five cycles provided satisfactory recoveries between 66 and 114% with SD of 
      between 1 and 14%. For preconcentration and purification tandem MAX-HLB 
      cartridges were used. The volume and composition was optimized and the highest 
      recoveries were obtained with a combination of methanol-aqueous ammonia solution. 
      The limits of quantification (LOQs) were between 0.2 and 2 ng g(-1) and linearity 
      higher than 0.98 for the majority of the selected pharmaceuticals. The method was 
      successfully applied to soil samples collected from the Jerez de la Frontera 
      agricultural region, irrigated with treated wastewater, and to sediment samples 
      from the River Guadalete. The detection of nine pharmaceuticals including 
      stimulants, antirheumatics, analgesics, anti-inflammatories, tranquilizers, and 
      veterinary medicines at ng g(-1) concentration levels was achieved.
FAU - Perez-Carrera, Erkuden
AU  - Perez-Carrera E
AD  - Departamento de Quimica Fisica, Facultad de Ciencias del Mar y Ambientales, 
      Universidad de Cadiz, Campus Rio San Pedro s/n, 11510, Puerto Real, Cadiz, Spain. 
      erkuden.perez@uca.es
FAU - Hansen, Martin
AU  - Hansen M
FAU - Leon, Victor M
AU  - Leon VM
FAU - Bjorklund, Erland
AU  - Bjorklund E
FAU - Krogh, Kristine A
AU  - Krogh KA
FAU - Halling-Sorensen, Bent
AU  - Halling-Sorensen B
FAU - Gonzalez-Mazo, Eduardo
AU  - Gonzalez-Mazo E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100619
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Soil Pollutants)
SB  - IM
MH  - Animals
MH  - Chromatography, Liquid/*methods
MH  - Drug Residues/*analysis
MH  - Geologic Sediments/*chemistry
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Limit of Detection
MH  - Soil Pollutants/*analysis
MH  - Solid Phase Microextraction
MH  - Tandem Mass Spectrometry/*methods
MH  - Temperature
EDAT- 2010/06/22 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/03/11 00:00 [received]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/05/12 00:00 [revised]
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1007/s00216-010-3862-x [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2010 Oct;398(3):1173-84. doi: 10.1007/s00216-010-3862-x. Epub 
      2010 Jun 19.