PMID- 20564154
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20221207
IS  - 0008-543X (Print)
IS  - 1097-0142 (Electronic)
IS  - 0008-543X (Linking)
VI  - 116
IP  - 14
DP  - 2010 Jul 15
TI  - Access to hematopoietic stem cell transplantation: effect of race and sex.
PG  - 3469-76
LID - 10.1002/cncr.25297 [doi]
AB  - BACKGROUND: The purpose of the current study was to determine whether the use of 
      hematopoietic stem cell transplantation (HCT) to treat leukemia, lymphoma, or 
      multiple myeloma (MM) differs by race and sex. METHODS: The annual incidence of 
      leukemia, lymphoma, and MM was estimated in the United States in people aged <70 
      years by race and sex using the Surveillance, Epidemiology, and End Results 
      (SEER) cancer registry between 1997 and 2002 and US census reports for the year 
      2000. The annual incidence of autologous, human leukocyte antigen (HLA) identical 
      sibling, and unrelated HCT performed in these groups was estimated using Center 
      for International Blood and Marrow Transplant Research data from 1997 through 
      2002. Logistic regression analysis was used to calculate the age-adjusted odds 
      ratio (OR) of receiving HCT for Caucasians versus African Americans and for men 
      versus women. RESULTS: The likelihood of undergoing HCT was found to be higher 
      for Caucasians than for African Americans (OR, 1.40; 95% confidence interval [95% 
      CI], 1.34-1.46). This difference existed for each type of HCT: autologous (OR, 
      1.24; 95% CI, 1.19-1.30), HLA identical sibling (OR, 1.59; 95% CI, 1.46-1.74), 
      and unrelated donor (OR, 2.02; 95% CI, 1.75-2.33). Overall, men were more likely 
      than women to receive HCT (OR, 1.07; 95% CI, 1.05-1.1 [P<.0001]); however, this 
      difference was found to be significant only for autologous HCT (OR, 1.10; 95% CI, 
      1.07-1.13 [P<.0001]). CONCLUSIONS: HCT is more frequently used to treat leukemia, 
      lymphoma, and MM in Caucasians than in African American individuals. African 
      Americans have lower rates of both autologous and allogeneic HCT, indicating that 
      donor availability cannot fully explain the differences. Women are less likely 
      than men to receive autologous HCT for reasons unexplained by age or disease 
      status.
CI  - Copyright (c) 2010 American Cancer Society.
FAU - Joshua, Thomas V
AU  - Joshua TV
AD  - Center for Nursing Research, School of Nursing, Medical College of Georgia, 
      Augusta, Georgia 30912, USA. tjoshua@mcg.edu
FAU - Rizzo, J Douglas
AU  - Rizzo JD
FAU - Zhang, Mei-Jie
AU  - Zhang MJ
FAU - Hari, Parameswaran N
AU  - Hari PN
FAU - Kurian, Seira
AU  - Kurian S
FAU - Pasquini, Marcelo
AU  - Pasquini M
FAU - Majhail, Navneet S
AU  - Majhail NS
FAU - Lee, Stephanie J
AU  - Lee SJ
FAU - Horowitz, Mary M
AU  - Horowitz MM
LA  - eng
GR  - 5U01HL069294/HL/NHLBI NIH HHS/United States
GR  - U24 CA076518-14/CA/NCI NIH HHS/United States
GR  - U24 CA076518/CA/NCI NIH HHS/United States
GR  - HHSH234200637015C/PHS HHS/United States
GR  - U24-CA76518/CA/NCI NIH HHS/United States
GR  - U01 HL069294/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Black or African American
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Health Services Accessibility
MH  - Hematopoietic Stem Cell Transplantation/*statistics & numerical data
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Leukemia/ethnology/*therapy
MH  - Lymphoma/ethnology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*therapy
MH  - *Racial Groups
MH  - Sex Factors
MH  - Transplantation, Autologous
MH  - Transplantation, Homologous
MH  - United States
MH  - White People
PMC - PMC3153958
MID - NIHMS311623
EDAT- 2010/06/22 06:00
MHDA- 2010/08/20 06:00
PMCR- 2011/08/10
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
PHST- 2011/08/10 00:00 [pmc-release]
AID - 10.1002/cncr.25297 [doi]
PST - ppublish
SO  - Cancer. 2010 Jul 15;116(14):3469-76. doi: 10.1002/cncr.25297.