PMID- 20565840
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20221207
IS  - 1756-9966 (Electronic)
IS  - 0392-9078 (Print)
IS  - 0392-9078 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Jun 18
TI  - Alterations of dendritic cell subsets in the peripheral circulation of patients 
      with cervical carcinoma.
PG  - 78
LID - 10.1186/1756-9966-29-78 [doi]
AB  - Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic 
      cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, 
      the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the 
      peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients with 
      CIN, and 62 healthy individuals. A substantial reduction of circulating dendritic 
      cells and accordingly immunodepression may be associated with increased IL-6 and 
      TGF-beta in serum. These findings could give expression to the immunosuppression 
      of circulating dendritic cells in patients with CC and CIN, thus, may indicate 
      novel aspects of cervical carcinoma immune evasion.
FAU - Ye, Feng
AU  - Ye F
AD  - Women's Reproductive Health Key Laboratory of Zhejiang Province, Department of 
      Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, 
      Xueshi Rd#2, Hangzhou, 310006, China.
FAU - Yu, Yan
AU  - Yu Y
FAU - Hu, Yuting
AU  - Hu Y
FAU - Lu, Weiguo
AU  - Lu W
FAU - Xie, Xing
AU  - Xie X
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100618
PL  - England
TA  - J Exp Clin Cancer Res
JT  - Journal of experimental & clinical cancer research : CR
JID - 8308647
RN  - 0 (Cytokines)
SB  - IM
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - Dendritic Cells/immunology/*pathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Prognosis
MH  - Uterine Cervical Neoplasms/*blood/immunology/pathology
MH  - Uterine Cervical Dysplasia/*blood/immunology/pathology
PMC - PMC2904720
EDAT- 2010/06/23 06:00
MHDA- 2010/10/29 06:00
PMCR- 2010/06/18
CRDT- 2010/06/23 06:00
PHST- 2010/03/29 00:00 [received]
PHST- 2010/06/18 00:00 [accepted]
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
PHST- 2010/06/18 00:00 [pmc-release]
AID - 1756-9966-29-78 [pii]
AID - 10.1186/1756-9966-29-78 [doi]
PST - epublish
SO  - J Exp Clin Cancer Res. 2010 Jun 18;29(1):78. doi: 10.1186/1756-9966-29-78.