PMID- 20567820
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20211020
IS  - 1619-7089 (Electronic)
IS  - 1619-7070 (Linking)
VI  - 37
IP  - 11
DP  - 2010 Nov
TI  - Comparison of two neural network classifiers in the differential diagnosis of 
      essential tremor and Parkinson's disease by (123)I-FP-CIT brain SPECT.
PG  - 2146-53
LID - 10.1007/s00259-010-1481-6 [doi]
AB  - PURPOSE: To contribute to the differentiation of Parkinson's disease (PD) and 
      essential tremor (ET), we compared two different artificial neural network 
      classifiers using (123)I-FP-CIT SPECT data, a probabilistic neural network (PNN) 
      and a classification tree (ClT). METHODS: (123)I-FP-CIT brain SPECT with 
      semiquantitative analysis was performed in 216 patients: 89 with ET, 64 with PD 
      with a Hoehn and Yahr (H&Y) score of </=2 (early PD), and 63 with PD with a H&Y 
      score of >/=2.5 (advanced PD). For each of the 1,000 experiments carried out, 108 
      patients were randomly selected as the PNN training set, while the remaining 108 
      validated the trained PNN, and the percentage of the validation data correctly 
      classified in the three groups of patients was computed. The expected performance 
      of an "average performance PNN" was evaluated. In analogy, for ClT 1,000 
      classification trees with similar structures were generated. RESULTS: For PNN, 
      the probability of correct classification in patients with early PD was 81.9+/-8.1% 
      (mean+/-SD), in patients with advanced PD 78.9+/-8.1%, and in ET patients 96.6+/-2.6%. 
      For ClT, the first decision rule gave a mean value for the putamen of 5.99, which 
      resulted in a probability of correct classification of 93.5+/-3.4%. This means that 
      patients with putamen values >5.99 were classified as having ET, while patients 
      with putamen values <5.99 were classified as having PD. Furthermore, if the 
      caudate nucleus value was higher than 6.97 patients were classified as having 
      early PD (probability 69.8+/-5.3%), and if the value was <6.97 patients were 
      classified as having advanced PD (probability 88.1%+/-8.8%). CONCLUSION: These 
      results confirm that PNN achieved valid classification results. Furthermore, ClT 
      provided reliable cut-off values able to differentiate ET and PD of different 
      severities.
FAU - Palumbo, Barbara
AU  - Palumbo B
AD  - Department of Surgical, Radiological and Odontostomatological Sciences, 
      University of Perugia, S. Andrea delle Fratte, Perugia, Italy. mednuc@unipg.it
FAU - Fravolini, Mario Luca
AU  - Fravolini ML
FAU - Nuvoli, Susanna
AU  - Nuvoli S
FAU - Spanu, Angela
AU  - Spanu A
FAU - Paulus, Kai Stephan
AU  - Paulus KS
FAU - Schillaci, Orazio
AU  - Schillaci O
FAU - Madeddu, Giuseppe
AU  - Madeddu G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100623
PL  - Germany
TA  - Eur J Nucl Med Mol Imaging
JT  - European journal of nuclear medicine and molecular imaging
JID - 101140988
RN  - 0 (Tropanes)
RN  - 155797-99-2 (2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/*diagnostic imaging
MH  - Data Interpretation, Statistical
MH  - Diagnosis, Differential
MH  - Essential Tremor/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Neural Networks, Computer
MH  - Parkinson Disease/*diagnostic imaging
MH  - Probability
MH  - Tomography, Emission-Computed, Single-Photon/*methods
MH  - *Tropanes
EDAT- 2010/06/23 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/06/23 06:00
PHST- 2010/01/07 00:00 [received]
PHST- 2010/04/13 00:00 [accepted]
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - 10.1007/s00259-010-1481-6 [doi]
PST - ppublish
SO  - Eur J Nucl Med Mol Imaging. 2010 Nov;37(11):2146-53. doi: 
      10.1007/s00259-010-1481-6. Epub 2010 Jun 23.