PMID- 20569985
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20131121
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Oct
TI  - Distribution of blood concentrations of persistent organic pollutants in a 
      representative sample of the population of Catalonia.
PG  - 655-64
LID - 10.1016/j.envint.2010.04.013 [doi]
AB  - BACKGROUND: Although virtually all populations worldwide are commonly exposed to 
      numerous persistent organic pollutants (POPs) and human concentrations vary 
      widely, only a few countries conduct nationwide surveillance programs of POP 
      concentrations in representative samples of the general population. OBJECTIVE: To 
      evaluate the distribution of serum concentrations of nineteen POPs and their main 
      predictors in a representative sample of the general population of Catalonia. 
      METHODS: Participants in the Catalan Health Interview Survey aged 18-74 years 
      were interviewed face-to-face, gave blood, and underwent a physical exam. Graphs 
      (including "POP Geoffrey Rose curves") were used to represent the full population 
      distribution of each POP in the 919 participants. Through multivariate 
      statistical models we analyzed the influence on POP concentrations of sex, age, 
      body mass index (BMI), socioeconomic status and, in women, parity. RESULTS: We 
      detected dichlorodiphenyltrichloroethane (p,p'-DDT), 
      dichlorodiphenyldichloroethane (p,p'-DDE), polychlorinated biphenyls (PCBs) 
      congeners 118, 138, 153 and 180, hexachlorobenzene (HCB) and 
      beta-hexachlorocyclohexane (beta-HCH) in more than 85% of the subjects. p,p'-DDE, 
      HCB and beta-HCH showed the highest concentrations (median=399, 159 and 92 ng/g 
      lipid, respectively). Distributions were highly skewed and interindividual 
      differences were up to 7700-fold. POP levels differed significantly by gender, 
      age, BMI, educational level, and parity. CONCLUSIONS: In Catalonia, an advanced 
      European society, exposure to POPs remains common, a vast majority of the 
      population has much lower blood concentrations than a relative minority, and the 
      population distributions of POP are hence highly skewed to the right. Shifting 
      distributions towards lower concentrations requires more energetic policies and 
      population strategies.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Porta, Miquel
AU  - Porta M
AD  - Institut Municipal d'Investigacio Medica, Barcelona, Catalonia, Spain. 
      mporta@imim.es
FAU - Gasull, Magda
AU  - Gasull M
FAU - Puigdomenech, Elisa
AU  - Puigdomenech E
FAU - Gari, Merce
AU  - Gari M
FAU - Bosch de Basea, Magda
AU  - Bosch de Basea M
FAU - Guillen, Montserrat
AU  - Guillen M
FAU - Lopez, Tomas
AU  - Lopez T
FAU - Bigas, Esther
AU  - Bigas E
FAU - Pumarega, Jose
AU  - Pumarega J
FAU - Llebaria, Xavier
AU  - Llebaria X
FAU - Grimalt, Joan O
AU  - Grimalt JO
FAU - Tresserras, Ricard
AU  - Tresserras R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100531
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Demography
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - Environmental Exposure/*analysis/statistics & numerical data
MH  - *Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Epidemiological Monitoring
MH  - Female
MH  - Hexachlorobenzene/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Organic Chemicals/*blood
MH  - Polychlorinated Biphenyls/blood
MH  - Socioeconomic Factors
MH  - Spain/epidemiology
MH  - Young Adult
EDAT- 2010/06/24 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/03/12 00:00 [received]
PHST- 2010/04/12 00:00 [revised]
PHST- 2010/04/20 00:00 [accepted]
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
AID - S0160-4120(10)00065-6 [pii]
AID - 10.1016/j.envint.2010.04.013 [doi]
PST - ppublish
SO  - Environ Int. 2010 Oct;36(7):655-64. doi: 10.1016/j.envint.2010.04.013. Epub 2010 
      May 31.