PMID- 20570016
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20161125
IS  - 0212-6982 (Print)
IS  - 0212-6982 (Linking)
VI  - 29
IP  - 6
DP  - 2010 Nov-Dec
TI  - Influence of extracardiac activity and perfusion abnormalities on myocardial 
      perfusion gated SPECT parameters: interobserver analysis.
PG  - 293-8
LID - 10.1016/j.remn.2010.04.004 [doi]
AB  - OBJECTIVE: Extracardiac activity (ECA) may affect interpretation of gated SPECT 
      myocardial perfusion studies (MPSs). To solve this problem, available softwares 
      include myocardial edge delimitation. PURPOSE: To evaluate the influence of ECA 
      in automatic myocardial edge detection under normal conditions and with abnormal 
      perfusion and also evaluate the reproducibility of semi-automatic processing. 
      METHODS: A total of 100 MPSs, 50 with ECA, were analyzed. Each subgroup included 
      25 cases with perfusion abnormalities. The cases were processed automatically and 
      by 4 independent operators with different levels of experience. Commercial QGS 
      and QPS softwares were used with tools to mask and relocate the left ventricle 
      area. Functional parameters (final diastolic and systolic volumes and ejection 
      fraction) and perfusion parameters such as the reversibility perfusion score and 
      rest perfusion defect extension were analyzed. The data were compared with 
      Pearson's correlation and Student's test. RESULTS: Interobserver correlation 
      significantly worsened with the presence of ECA and was moderately affected by 
      perfusion abnormalities. More experienced observers presented better correlation. 
      Reproducibility was greater for the functional perfusion parameters, 
      independently of the observer's experience. CONCLUSIONS: ECA significantly 
      affects automatic edging delimitation, affecting the MPS values. Interobserver 
      reproducibility with manual processing was more altered regarding functional 
      parameters than in the perfusion scores. Perfusion abnormalities did not 
      interfere with software reproducibility, and when present, better correlation was 
      found. If ECA is not present, manual intervention should be avoided.
CI  - Copyright (c) 2010 Elsevier Espana, S.L. y SEMNIM. All rights reserved.
FAU - Jaimovich, R
AU  - Jaimovich R
AD  - Nuclear Medicine Section, Medicine Department, University of Chile, Clinical 
      Hospital, Santos Dumont 999-1E, Independencia, Santiago, Chile. 
      rodrigo@jaimovich.cl
FAU - Gutierrez, D
AU  - Gutierrez D
FAU - Lavados, H
AU  - Lavados H
FAU - Aqueveque, C
AU  - Aqueveque C
FAU - Quevedo, L
AU  - Quevedo L
FAU - Alay, R
AU  - Alay R
FAU - Massardo, T
AU  - Massardo T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100531
PL  - Spain
TA  - Rev Esp Med Nucl
JT  - Revista espanola de medicina nuclear
JID - 9208726
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Thallium Radioisotopes)
RN  - 971Z4W1S09 (Technetium Tc 99m Sestamibi)
SB  - IM
MH  - Aged
MH  - *Artifacts
MH  - Automation
MH  - *Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
MH  - Female
MH  - Humans
MH  - Intestines/diagnostic imaging
MH  - Liver/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*diagnostic imaging/pathology
MH  - *Myocardial Perfusion Imaging
MH  - *Observer Variation
MH  - *Radiopharmaceuticals/pharmacokinetics
MH  - Reproducibility of Results
MH  - Software
MH  - Stroke Volume
MH  - *Technetium Tc 99m Sestamibi/pharmacokinetics
MH  - Thallium Radioisotopes/pharmacokinetics
MH  - Tissue Distribution
EDAT- 2010/06/24 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/01/12 00:00 [received]
PHST- 2010/04/01 00:00 [revised]
PHST- 2010/04/09 00:00 [accepted]
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - S0212-6982(10)00067-4 [pii]
AID - 10.1016/j.remn.2010.04.004 [doi]
PST - ppublish
SO  - Rev Esp Med Nucl. 2010 Nov-Dec;29(6):293-8. doi: 10.1016/j.remn.2010.04.004. Epub 
      2010 May 31.