PMID- 20570952
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20220330
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 31
IP  - 15
DP  - 2010 Aug
TI  - Iron deficiency: an ominous sign in patients with systolic chronic heart failure.
PG  - 1872-80
LID - 10.1093/eurheartj/ehq158 [doi]
AB  - AIMS: Beyond erythropoiesis, iron is involved in numerous biological processes 
      crucial for maintenance of homeostasis. Patients with chronic heart failure (CHF) 
      are prone to develop iron deficiency (ID), and iron supplementation improves 
      their functional status and quality of life. We sought to examine the 
      relationship between ID and survival in patients with systolic CHF. METHODS AND 
      RESULTS: In a prospective observational study, we evaluated 546 patients with 
      stable systolic CHF [age: 55 +/- 11 (mean +/- standard deviation) years, males: 
      88%, left ventricular ejection fraction: 26 +/- 7%, New York Heart Association 
      (NYHA) class (I/II/III/IV): 57/221/226/42]. Iron deficiency was defined as: 
      ferritin <100 microg/L, or 100-300 microg/L with transferrin saturation <20%. The 
      prevalence of ID was 37 +/- 4% [+/-95% confidence intervals (CI)] in the entire 
      CHF population (32 +/- 4 vs. 57 +/- 10%-in subjects without vs. with anaemia 
      defined as haemoglobin level <12 g/dL in women and <13 g/dL in men, P < 0.001). 
      In a multiple logistic model, ID was more prevalent in women, those in the 
      advanced NYHA class, with higher plasma N-terminal pro-type B natriuretic peptide 
      and higher serum high-sensitivity C-reactive protein (all P < 0.05). At the end 
      of follow-up (mean duration: 731 +/- 350 days), there were 153 (28%) deaths and 
      30 (6%) heart transplantations (HTX). In multivariable models, ID (but not 
      anaemia) was related to an increased risk of death or HTX (adjusted hazard ratio 
      1.58, 95% CI 1.14-2.17, P < 0.01). CONCLUSION: In patients with systolic CHF, ID 
      is common and constitutes a strong, independent predictor of unfavourable 
      outcome. Iron supplementation may be considered as a therapeutic approach in 
      these patients to improve prognosis.
FAU - Jankowska, Ewa A
AU  - Jankowska EA
AD  - Department of Heart Diseases, Wroclaw Medical University, Centre for Heart 
      Diseases, Military Hospital, ul. Weigla 5, Wroclaw, Poland. 
      ewa.jankowska@antro.pan.wroc.pl
FAU - Rozentryt, Piotr
AU  - Rozentryt P
FAU - Witkowska, Agnieszka
AU  - Witkowska A
FAU - Nowak, Jolanta
AU  - Nowak J
FAU - Hartmann, Oliver
AU  - Hartmann O
FAU - Ponikowska, Beata
AU  - Ponikowska B
FAU - Borodulin-Nadzieja, Ludmila
AU  - Borodulin-Nadzieja L
FAU - Banasiak, Waldemar
AU  - Banasiak W
FAU - Polonski, Lech
AU  - Polonski L
FAU - Filippatos, Gerasimos
AU  - Filippatos G
FAU - McMurray, John J V
AU  - McMurray JJ
FAU - Anker, Stefan D
AU  - Anker SD
FAU - Ponikowski, Piotr
AU  - Ponikowski P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100621
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Peptide Fragments)
RN  - 0 (Transferrin)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9007-73-2 (Ferritins)
SB  - IM
EIN - Eur Heart J. 2011 May;32(9):1054
MH  - Aged
MH  - C-Reactive Protein/metabolism
MH  - Chronic Disease
MH  - Disease-Free Survival
MH  - Female
MH  - Ferritins/blood
MH  - Heart Failure, Systolic/*complications/metabolism
MH  - Humans
MH  - *Iron Deficiencies
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/metabolism
MH  - Peptide Fragments/metabolism
MH  - Prognosis
MH  - Prospective Studies
MH  - Transferrin/metabolism
EDAT- 2010/06/24 06:00
MHDA- 2011/07/29 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
AID - ehq158 [pii]
AID - 10.1093/eurheartj/ehq158 [doi]
PST - ppublish
SO  - Eur Heart J. 2010 Aug;31(15):1872-80. doi: 10.1093/eurheartj/ehq158. Epub 2010 
      Jun 21.