PMID- 20571304
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20220408
IS  - 1598-9992 (Print)
IS  - 1598-9992 (Linking)
VI  - 55
IP  - 6
DP  - 2010 Jun
TI  - [The trend of eradication rate of Helicobacter pylori infection and clinical 
      factors that affect the eradication of first-line therapy].
PG  - 368-75
AB  - BACKGROUND/AIMS: Although triple combination therapy containing a proton pump 
      inhibitor (PPI) and two antibiotics is considered as a standard regimen for the 
      first-line anti-Helicobacter pylori treatment, the recent trend of eradication 
      rates following this therapy has been declined in the last few years. The purpose 
      of this study was to investigate the trend of H. pylori eradication rates over 
      the last 9 years and to evaluate are clinical factors affecting eradication 
      rates. METHODS: From January 2001 to June 2009, H. pylori eradication rates in 
      709 patients with documented H. pylori infection who received triple combination 
      therapy for 7 days were retrospectively evaluated according to years and various 
      clinical factors. H. pylori status was evaluated by 13C urea breath test 4-6 
      weeks after completion of treatment. results: The overall H. pylori eradication 
      rate was 77.0%. The annual eradication rates from year 2001 to 2009 were 78.9%, 
      72.5%, 81.0%, 75.0%, 79.1%, 77.1%, 77.8%, 77.8%, and 75.0% by per-protocol 
      analysis. There was no decreasing tendency of the eradiation rate over 9 years 
      (p=0.974). There was no statistical difference in the eradication rates according 
      to age, sex, smoking, alcohol, NSAIDs, underlying diseases, endoscopic diagnosis, 
      and PPI. However, the eradication rate was lower in patients who took aspirin 
      (OR=0.509, 95% CI=0.292-0.887, p=0.001) and antibiotics within 6 months 
      (OR=0.347, 95% CI=0.183-0.658, p=0.001). CONCLUSIONS: The H. pylori eradication 
      rate has not changed at Gwangju-Chonnam province in Korea for recent 9 years. 
      Lower eradication rate in aspirin and antibiotics users warrants further 
      attention.
FAU - Cho, Dong Keun
AU  - Cho DK
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Park, Seon Young
AU  - Park SY
FAU - Kee, Won Ju
AU  - Kee WJ
FAU - Lee, Jeong Hyeon
AU  - Lee JH
FAU - Ki, Ho Seok
AU  - Ki HS
FAU - Yoon, Kyung-Won
AU  - Yoon KW
FAU - Cho, Sung Bum
AU  - Cho SB
FAU - Lee, Wan Sik
AU  - Lee WS
FAU - Joo, Young Eun
AU  - Joo YE
FAU - Kim, Hyun Soo
AU  - Kim HS
FAU - Choi, Sung Kyu
AU  - Choi SK
FAU - Rew, Jong Sun
AU  - Rew JS
LA  - kor
PT  - Journal Article
PL  - Korea (South)
TA  - Korean J Gastroenterol
JT  - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JID - 101189416
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Aspirin/therapeutic use
MH  - Child
MH  - Drug Therapy, Combination
MH  - Female
MH  - Helicobacter Infections/diagnosis/*drug therapy
MH  - *Helicobacter pylori
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2010/06/24 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 10.4166/kjg.2010.55.6.368 [doi]
PST - ppublish
SO  - Korean J Gastroenterol. 2010 Jun;55(6):368-75. doi: 10.4166/kjg.2010.55.6.368.