PMID- 20571919
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20211020
IS  - 1573-742X (Electronic)
IS  - 0929-5305 (Linking)
VI  - 30
IP  - 3
DP  - 2010 Oct
TI  - Successful use of fondaparinux in a patient with a mechanical heart valve 
      replacement and a history of heparin-induced thrombocytopenia.
PG  - 375-7
LID - 10.1007/s11239-010-0494-0 [doi]
AB  - The development of heparin-induced thrombocytopenia (HIT) is an antibody-mediated 
      clinicopathologic syndrome. The resultant thrombocytopenia and thrombosis can be 
      severe and life-threatening. Fondaparinux is a parenteral factor Xa inhibitor 
      used for venous thromboembolism prevention and treatment. Fondaparinux has 
      minimal affinity for platelet factor 4, making it an alternative agent to 
      unfractionated heparin (UFH) and low-molecular weight heparin (LMWH) and a 
      plausible consideration for patients with a history of HIT. The use of 
      fondaparinux in patients with mechanical heart valve replacement and a history of 
      HIT has never been discussed in the literature. We report on the case of a 
      patient with a mechanical aortic heart valve replacement and a history of HIT who 
      was successfully bridged postoperatively with fondaparinux. While there is 
      currently no literature to support the use of fondaparinux in patients with 
      mechanical heart valves, this drug may offer an option for management of such 
      patients who cannot use heparin products. However, further clinical 
      investigations are warranted to confirm both the safety and efficacy of this 
      agent in the mechanical heart valve population.
FAU - Corbett, Tia L
AU  - Corbett TL
AD  - Department of Pharmacy, Sinai-Grace Hospital, Detroit Medical Center, 6071 W 
      Outer Drive, Detroit, MI 48235, USA. tcorbett@dmc.org
FAU - Elher, Kathy S
AU  - Elher KS
FAU - Garwood, Candice L
AU  - Garwood CL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - J Thromb Thrombolysis
JT  - Journal of thrombosis and thrombolysis
JID - 9502018
RN  - 0 (Anticoagulants)
RN  - 0 (Polysaccharides)
RN  - 9005-49-6 (Heparin)
RN  - J177FOW5JL (Fondaparinux)
SB  - IM
MH  - Adult
MH  - Anticoagulants
MH  - Aortic Valve/surgery
MH  - Female
MH  - Fondaparinux
MH  - *Heart Valve Prosthesis Implantation
MH  - Heparin/*adverse effects
MH  - Humans
MH  - Polysaccharides/*therapeutic use
MH  - Postoperative Care
MH  - Therapeutics
MH  - Thrombocytopenia/*chemically induced
EDAT- 2010/06/24 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.1007/s11239-010-0494-0 [doi]
PST - ppublish
SO  - J Thromb Thrombolysis. 2010 Oct;30(3):375-7. doi: 10.1007/s11239-010-0494-0.