PMID- 20573834
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20211020
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 84
IP  - 17
DP  - 2010 Sep
TI  - Distinct intracellular trafficking of hepatitis C virus in myeloid and 
      plasmacytoid dendritic cells.
PG  - 8964-9
LID - 10.1128/JVI.00517-10 [doi]
AB  - Dendritic cells (DCs) are of pivotal importance for the initiation of immune 
      responses to control and eliminate viral infections. The molecular mechanisms of 
      hepatitis C virus (HCV) antigen uptake and processing by blood DCs are poorly 
      defined. Here we show that human blood DC subsets acquire HCV independent of the 
      classical HCV entry factors. Following HCV uptake, human plasmacytoid and myeloid 
      DC subsets deliver HCV antigen into distinct endocytotic compartments, which are 
      dedicated to presentation to CD4(+) or CD8(+) T cells. Our findings support a 
      model of HCV antigen processing and presentation in which DC subsets fulfill 
      distinct functions.
FAU - Lambotin, Melanie
AU  - Lambotin M
AD  - INSERM U748, Universite de Strasbourg, 67000 Strasbourg, France.
FAU - Baumert, Thomas F
AU  - Baumert TF
FAU - Barth, Heidi
AU  - Barth H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100623
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Hepatitis C Antigens)
SB  - IM
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology/metabolism/virology
MH  - Hepacivirus/*immunology/physiology
MH  - Hepatitis C/*immunology/metabolism/virology
MH  - Hepatitis C Antigens/immunology/metabolism
MH  - Humans
MH  - Myeloid Cells/immunology/metabolism/*virology
MH  - Protein Transport
PMC - PMC2918984
EDAT- 2010/06/25 06:00
MHDA- 2010/09/18 06:00
PMCR- 2011/03/01
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - JVI.00517-10 [pii]
AID - 0517-10 [pii]
AID - 10.1128/JVI.00517-10 [doi]
PST - ppublish
SO  - J Virol. 2010 Sep;84(17):8964-9. doi: 10.1128/JVI.00517-10. Epub 2010 Jun 23.