PMID- 20574602
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20201209
IS  - 1651-2057 (Electronic)
IS  - 0001-5555 (Linking)
VI  - 90
IP  - 4
DP  - 2010 Jul
TI  - Ethosome formulations of known contact allergens can increase their sensitizing 
      capacity.
PG  - 374-8
LID - 10.2340/00015555-0874 [doi]
AB  - Vesicular systems, such as liposomes and ethosomes, are used in cosmetic and 
      pharmaceutical products to encapsulate ingredients, to protect ingredients from 
      degradation, to increase bioavailability, and to improve cosmetic performance. 
      Some reports have suggested that formulation of cosmetic ingredients in vesicular 
      carrier systems may increase their contact allergy elicitation potential in 
      humans. However, no sensitization studies have been published. We formulated two 
      model contact allergens (isoeugenol and dinitrochlorobenzene) in ethosomes and 
      investigated the sensitization response using a modified local lymph node assay 
      (LLNA). The results were compared with those for the same allergens in similar 
      concentrations and vehicles without ethosomes. Both allergens encapsulated in 
      200-300 nm ethosomes showed increased sensitizing potency in the murine assay 
      compared with the allergens in solution without ethosomes. Empty ethosomes were 
      non-sensitizing according to LLNA. The clinical implications are so far 
      uncertain, but increased allergenicity from ethosome-encapsulated topical product 
      ingredients cannot be excluded.
FAU - Madsen, Jacob Torp
AU  - Madsen JT
AD  - National Allergy Research Centre, Department of Dermatology and Allergy Centre, 
      Odense University Hospital, Odense, Denmark. jakobtorp@dadlnet.dk
FAU - Vogel, Stefan
AU  - Vogel S
FAU - Karlberg, Ann-Therese
AU  - Karlberg AT
FAU - Simonsson, Carl
AU  - Simonsson C
FAU - Johansen, Jeanne D
AU  - Johansen JD
FAU - Andersen, Klaus E
AU  - Andersen KE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (Allergens)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Liposomes)
RN  - 3T8H1794QW (Eugenol)
RN  - 5M0MWY797U (isoeugenol)
SB  - IM
MH  - Allergens/*administration & dosage/immunology
MH  - Animals
MH  - Cell Proliferation/*drug effects
MH  - Chemistry, Pharmaceutical
MH  - Dermatitis, Allergic Contact/*etiology/immunology
MH  - Dinitrochlorobenzene/*administration & dosage/immunology
MH  - Dose-Response Relationship, Drug
MH  - Drug Compounding
MH  - Eugenol/administration & dosage/*analogs & derivatives/immunology
MH  - Female
MH  - *Immunization
MH  - Liposomes
MH  - Local Lymph Node Assay
MH  - Lymph Nodes/*drug effects/immunology/pathology
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Particle Size
EDAT- 2010/06/25 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - 10.2340/00015555-0874 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 2010 Jul;90(4):374-8. doi: 10.2340/00015555-0874.