PMID- 20578492
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20100628
IS  - 0125-1562 (Print)
IS  - 0125-1562 (Linking)
VI  - 41
IP  - 1
DP  - 2010 Jan
TI  - Immune reconstitution inflammatory syndrome in adult human immunodeficiency 
      virus-infected patients in Thailand.
PG  - 138-45
AB  - Immune reconstitution inflammatory syndrome (IRIS) is an important adverse event 
      among human immunodeficiency virus (HIV)-infected patients taking highly active 
      antiretroviral therapy (HAART). The epidemiology of IRIS in Thailand has not been 
      well examined, especially among adult HIV-infected patients. In the present 
      study, we reviewed the medical records of 174 HIV-infected, antiretroviral 
      therapy-naive patients older than 15 years (the median CD4 count at commencement 
      of HAART was 37 cells/mm3) and compared characteristics of patients with and 
      without IRIS. During a 12-month follow-up period after commencement of HAART, 11 
      cases (6.3%) of IRIS were identified (4.2/100 patient-years HAART). The cases 
      included nine cases with mycobacterial infection, one with cytomegalovirus 
      retinitis and one with cryptococcal meningitis. The patients with IRIS were 
      significantly younger than those without IRIS (29 vs 36 on medians, p = 0.022). 
      The median interval between commencement of HAART and the onset of IRIS was 22 
      days. Although all patients with IRIS improved with or without corticosteroids, 
      they were more frequently hospitalized during a 12-month follow-up period while 
      taking HAART (1 vs 0 on medians, p < 0.001). The incidence of IRIS in advanced 
      adult HIV-infected patients in Thailand was lower than that reported from Europe 
      and the United States, which may be attributable to deferment of HAART after 
      diagnosing opportunistic infections.
FAU - Aramaki, Maie
AU  - Aramaki M
AD  - Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol 
      University, Bangkok. Thailand.
FAU - Silachamroon, Udomsak
AU  - Silachamroon U
FAU - Desakorn, Varunee
AU  - Desakorn V
FAU - Maek-A-nantawat, Wirach
AU  - Maek-A-nantawat W
FAU - Waiwaruwut, Jirachai
AU  - Waiwaruwut J
FAU - Jutiwarakun, Kamonwan
AU  - Jutiwarakun K
FAU - Kim, Jerome Hahn
AU  - Kim JH
FAU - Pitisuttithum, Punnee
AU  - Pitisuttithum P
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Southeast Asian J Trop Med Public Health
JT  - The Southeast Asian journal of tropical medicine and public health
JID - 0266303
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/etiology
MH  - Adolescent
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - CD4 Lymphocyte Count
MH  - Female
MH  - HIV Infections/*complications/*drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications/drug therapy
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Thailand
MH  - Viral Load
MH  - Young Adult
EDAT- 2010/06/29 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
PST - ppublish
SO  - Southeast Asian J Trop Med Public Health. 2010 Jan;41(1):138-45.