PMID- 20579683
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20171116
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 81
IP  - 2
DP  - 2010 Sep
TI  - Ecotoxicological assessment of surfactants in the aquatic environment: combined 
      toxicity of docusate sodium with chlorinated pollutants.
PG  - 288-93
LID - 10.1016/j.chemosphere.2010.05.050 [doi]
AB  - The toxicity of perfluorinated surfactants perfluorooctane sulfonic acid (PFOS), 
      perfluorooctanoic acid (PFOA), perfluorobutane sulfonate (PFBS) and PF-656 as 
      well as the sulfosuccinate surfactant docusate sodium has been examined using two 
      bioluminescence inhibition assays based on the marine bacterium Vibrio fischeri 
      and the self-luminescent cyanobacterial recombinant strain Anabaena CPB4337. We 
      also determined multigenerational toxicity towards the growth of the algae 
      Pseudokirchneriella subcapitata. With EC(50) values in the 43-75 mg/L range, 
      docusate sodium exhibited a higher toxicity towards the three organisms than 
      PFOS, PFOA, PF-656 and PFBS. We investigated the toxicological interactions of 
      the most toxic surfactant, docusate sodium, with two chlorinated compounds, 
      triclosan and 2,4,6-trichlorophenol (TCP), in their binary and ternary mixtures 
      using the method of the combination index based on the median-effect equation. In 
      general, the binary mixture of the chlorinated compounds triclosan and TCP 
      exhibited antagonism, which was stronger for the growth test using P. 
      subcapitata. Except for the green alga, the binary mixtures of docusate sodium 
      with TCP or triclosan showed synergism at medium to high effect levels; the 
      synergistic behaviour predominating in the ternary mixture and in the three 
      tested species. This result highlights the potential toxicological risk 
      associated with the co-occurrence of this surfactant with other pollutants.
CI  - (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Rosal, Roberto
AU  - Rosal R
AD  - Departamento de Ingenieria Quimica, Universidad de Alcala, E-28871, Alcala de 
      Henares, Madrid, Spain. roberto.rosal@uah.es
FAU - Rodea-Palomares, Ismael
AU  - Rodea-Palomares I
FAU - Boltes, Karina
AU  - Boltes K
FAU - Fernandez-Pinas, Francisca
AU  - Fernandez-Pinas F
FAU - Leganes, Francisco
AU  - Leganes F
FAU - Petre, Alice
AU  - Petre A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100625
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Chlorine Compounds)
RN  - 0 (Drug Combinations)
RN  - 0 (Fluorocarbons)
RN  - 0 (Salicylates)
RN  - 0 (Surface-Active Agents)
RN  - 0 (Water Pollutants, Chemical)
RN  - 10041-19-7 (Dioctyl Sulfosuccinic Acid)
RN  - 4NM5039Y5X (Triclosan)
RN  - 4R7X1O2820 (Chlorine)
RN  - 80186-96-5 (TCP (antiseptic))
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9679TC07X4 (Iodine)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - SE4TWR0K2C (perfluorobutane)
SB  - IM
MH  - Aliivibrio fischeri/drug effects
MH  - Alkanesulfonic Acids/toxicity
MH  - Anabaena/drug effects
MH  - Caprylates/toxicity
MH  - Chlorine/toxicity
MH  - Chlorine Compounds/*toxicity
MH  - Chlorophyta/drug effects
MH  - Dioctyl Sulfosuccinic Acid/*toxicity
MH  - Drug Combinations
MH  - Drug Interactions
MH  - Fluorocarbons/*toxicity
MH  - Iodine/toxicity
MH  - Salicylates/toxicity
MH  - Surface-Active Agents/*toxicity
MH  - Toxicity Tests
MH  - Triclosan/toxicity
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2010/06/29 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/03/05 00:00 [received]
PHST- 2010/05/25 00:00 [revised]
PHST- 2010/05/30 00:00 [accepted]
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - S0045-6535(10)00641-7 [pii]
AID - 10.1016/j.chemosphere.2010.05.050 [doi]
PST - ppublish
SO  - Chemosphere. 2010 Sep;81(2):288-93. doi: 10.1016/j.chemosphere.2010.05.050. Epub 
      2010 Jun 25.