PMID- 20580320
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20100816
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 18
IP  - 4
DP  - 2010 Aug
TI  - MELAS with recurrent complex partial seizures, nonconvulsive status epilepticus, 
      psychosis, and behavioral disturbances: case analysis with literature review.
PG  - 494-7
LID - 10.1016/j.yebeh.2010.05.020 [doi]
AB  - Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes (MELAS) is 
      a progressive neurodegenerative disorder associated with polygenetic, maternally 
      inherited, mitochondrial DNA mutations. MELAS has multisystem presentation 
      including neurological, muscular, endocrine, auditory, visual, cardiac, 
      psychiatric, renal, gastrointestinal and dermatological symptoms. Clinical course 
      and prognosis are variable, often leading to cognitive decline, disability, and 
      premature death. Both convulsive status epilepticus (CSE) and nonconvulsive 
      status epilepticus (NCSE) are reported with MELAS. This report illustrates a case 
      of MELAS with recurrent complex partial seizures, NCSE, confusion, aggressive 
      behaviors, hallucinations, and paranoid delusions. Rapid video/EEG confirmation 
      of diagnosis and aggressive antiepileptic drug intervention are required. Further 
      education of medical professionals regarding this disorder, its appropriate 
      management, and the significance of NCSE is indicated to avoid delay of 
      treatment.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Kaufman, Kenneth R
AU  - Kaufman KR
AD  - Department of Psychiatry, UMDNJ-Robert Wood Johnson Medical School, New 
      Brunswick, NJ 08901, USA. kaufmakr@umdnj.edu
FAU - Zuber, Nicole
AU  - Zuber N
FAU - Rueda-Lara, Maria A
AU  - Rueda-Lara MA
FAU - Tobia, Anthony
AU  - Tobia A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20100626
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Adult
MH  - Behavioral Symptoms/*complications
MH  - Epilepsy, Generalized/*complications
MH  - Humans
MH  - MELAS Syndrome/*complications
MH  - Male
MH  - Seizures/*complications
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2009/01/13 00:00 [received]
PHST- 2010/05/20 00:00 [revised]
PHST- 2010/05/22 00:00 [accepted]
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1525-5050(10)00389-6 [pii]
AID - 10.1016/j.yebeh.2010.05.020 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2010 Aug;18(4):494-7. doi: 10.1016/j.yebeh.2010.05.020. Epub 2010 
      Jun 26.