PMID- 20580654
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20100719
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 8
DP  - 2010 Aug
TI  - Association of killer cell immunoglobulin-like receptors and human leukocyte 
      antigen-C genotypes in South Brazilian with type 1 diabetes.
PG  - 799-803
LID - 10.1016/j.humimm.2010.05.014 [doi]
AB  - Type 1 diabetes mellitus (T1D) is a multifactorial and chronic autoimmune disease 
      caused by the deficiency of insulin synthesis and or by its secretion or action 
      defects. Genetic and environmental factors are known to be involved in its 
      pathogenesis. The human leukocyte antigen complex (human leukocyte antigen (HLA)) 
      constitutes the most relevant region contributing with 50% of the inherited risk 
      for T1D. Natural killer cells (NK) are part of the innate immune system 
      recognizing class I HLA molecules on target cells through their membrane 
      receptors, called killer immunoglobulin-like receptors (KIR). The aim of our 
      study is to evaluate the association between the KIR genes and HLA alleles in 
      patients with T1D and healthy controls. Two hundred forty-eight T1D patients and 
      250 healthy controls were typed for HLA and KIR genes by PCR-SSP. Our results 
      showed an increase of C2 in controls (p = 0.002). The genotype 2DL1/C2+ was also 
      more common in controls (p = 0.001), as well as haplotype association 
      KIR2DL2/DR3/DR4+ and the combination with only DR3+ (p < 0.001; p < 0.001). The 
      maximum protection was seen when KIR2DL2/DR3-were absent when the combination of 
      KIR2DL1/C2+ were present (p < 0.001) and the maximum risk was observed when 
      KIR2DL2/DR3/DR4+ were present in the absence of KIR2DL1/C2- (p = 0.005). Our 
      results confirmed the association of the KIR2DL2/DR3 increasing risk for T1D and 
      suggest a protective role of KIR2DL1/C2.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Jobim, Mariana
AU  - Jobim M
AD  - Department of Immunology, Hospital de Clinicas, Porto Alegre, Brazil; 
      Postgraduate Course in Medical Sciences, Federal University of Rio Grande do Sul, 
      Porto Alegre, Brazil. mjobim@hcpa.ufrgs.br
FAU - Chagastelles, Pedro
AU  - Chagastelles P
FAU - Salim, Patricia H
AU  - Salim PH
FAU - Portela, Pamela
AU  - Portela P
FAU - Wilson, Timothy J
AU  - Wilson TJ
FAU - Curti, Alessandra G
AU  - Curti AG
FAU - Jobim, Maria Regina
AU  - Jobim MR
FAU - Joao, Daniele A
AU  - Joao DA
FAU - Nardi, Nance Beyer
AU  - Nardi NB
FAU - Tschiedel, Balduino
AU  - Tschiedel B
FAU - Jobim, Luiz Fernando
AU  - Jobim LF
FAU - Roesler, Rafael
AU  - Roesler R
FAU - Schwartsmann, Gilberto
AU  - Schwartsmann G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100516
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-C Antigens)
RN  - 0 (KIR2DL1 protein, human)
RN  - 0 (KIR2DL4 protein, human)
RN  - 0 (KIR3DL2 protein, human)
RN  - 0 (KIR3DL3 protein, human)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL1)
RN  - 0 (Receptors, KIR2DL4)
RN  - 0 (Receptors, KIR3DL2)
SB  - IM
MH  - Adolescent
MH  - Brazil
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-C Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Polymerase Chain Reaction
MH  - Receptors, KIR/genetics
MH  - Receptors, KIR2DL1/*genetics
MH  - Receptors, KIR2DL4/genetics
MH  - Receptors, KIR3DL2/genetics
EDAT- 2010/06/29 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/02/19 00:00 [received]
PHST- 2010/02/19 00:00 [revised]
PHST- 2010/05/12 00:00 [accepted]
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - S0198-8859(10)00125-4 [pii]
AID - 10.1016/j.humimm.2010.05.014 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Aug;71(8):799-803. doi: 10.1016/j.humimm.2010.05.014. Epub 2010 
      May 16.