PMID- 20580983
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20181201
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 185
IP  - 1-2
DP  - 2011 Jan 30
TI  - Propofol pretreatment increases antidepressant-like effects induced by acute 
      administration of ketamine in rats receiving forced swimming test.
PG  - 248-53
LID - 10.1016/j.psychres.2010.04.046 [doi]
AB  - Animal and clinical studies have demonstrated that ketamine has quick, obvious 
      and persistent antidepressant-like effect, but such side effects as 
      cardiovascular system excitement and hallucinogenic activity have limited its 
      clinical application. Intravenous anesthetic propofol can remarkably inhibit or 
      eliminate ketamine's side effects including cardiovascular system excitement and 
      hallucinogenic activity even in a sub-anesthesia dose. However, effect of 
      propofol on rapid antidepressant-like action induced by ketamine still remains 
      unclear. The present study aimed to investigate effect of pretreatment with 
      propofol on the ketamine-induced rapid antidepressant-like action in rats 
      receiving forced swimming test. Open field test and forced swimming test were 
      used to investigate behavior changes of rats receiving different medication. 
      Expression of brain derived neurotrophic factors (BDNF) and 
      a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) pGluR1-Ser845 in 
      hippocampus was measured with sandwich-ELISA and Western Blot, respectively. 
      Results demonstrated that rats receiving propofol alone showed neither 
      antidepressant-like effects nor increased BDNF content; pretreatment with 
      propofol could increase the ketamine-induced antidepressant-like effects and the 
      expression of AMPA pGluR1-Ser845 in hippocampus, but could not further reinforce 
      the increased BDNF content induced by ketamine in hippocampus; after AMPA 
      receptor was antagonized, the strengthening effect of propofol on 
      ketamine-induced antidepressant-like action significantly decreased. The results 
      indicated that propofol in a sub-anesthetic dose could increase the 
      ketamine-induced antidepressant-like effect.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Wang, Xiaobin
AU  - Wang X
AD  - Infection and Immunology Research Laboratory, Affiliated Hospital of Luzhou 
      Medical College, Luzhou, Sichuan Province, China, 646000. wangxiaobin67@yahoo.cn
FAU - Yang, Yilin
AU  - Yang Y
FAU - Zhou, Xian
AU  - Zhou X
FAU - Wu, Jiali
AU  - Wu J
FAU - Li, Jiali
AU  - Li J
FAU - Jiang, Xian
AU  - Jiang X
FAU - Qu, Qiang
AU  - Qu Q
FAU - Ou, Cehua
AU  - Ou C
FAU - Liu, Li
AU  - Liu L
FAU - Zhou, Shuzhi
AU  - Zhou S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100523
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, AMPA)
RN  - 690G0D6V8H (Ketamine)
RN  - TFZ3H25BS1 (glutamate receptor ionotropic, AMPA 1)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*therapeutic use
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/*drug therapy/pathology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Drug Synergism
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Exploratory Behavior/drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/metabolism
MH  - Immobility Response, Tonic/drug effects
MH  - Ketamine/*therapeutic use
MH  - Male
MH  - Propofol/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, AMPA/metabolism
MH  - Swimming/*psychology
EDAT- 2010/06/29 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/06/29 06:00
PHST- 2009/09/15 00:00 [received]
PHST- 2010/03/30 00:00 [revised]
PHST- 2010/04/27 00:00 [accepted]
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - S0165-1781(10)00232-5 [pii]
AID - 10.1016/j.psychres.2010.04.046 [doi]
PST - ppublish
SO  - Psychiatry Res. 2011 Jan 30;185(1-2):248-53. doi: 10.1016/j.psychres.2010.04.046. 
      Epub 2010 May 23.