PMID- 20583303
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20220523
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 94
IP  - 2
DP  - 2010 Aug
TI  - Synthesis and characterization of a Hyaluronan-polyethylene copolymer for 
      biomedical applications.
PG  - 441-446
LID - 10.1002/jbm.b.31672 [doi]
AB  - Hyaluronan (HA)-based biomaterials are of interest for bone and cartilage tissue 
      engineering because HA plays an important role in orthopedic tissue development, 
      function, and repair. The goal of this project was to develop a biomaterial that 
      incorporated the constituents of both a hydrogel and a hydrophobic polymer for 
      biomedical applications. A series of amphiphilic graft copolymers consisting of 
      HA, a glycosaminoglycan, and high-density polyethylene (HDPE), that is, 
      HA-co-HDPE, were fabricated. The chemical characteristics, physical and 
      viscoelastic properties, and cytocompatibility of novel HA-co-HDPE materials were 
      characterized via Fourier Transform infrared (FTIR) spectroscopy, solid state 
      nuclear magnetic resonance (ssNMR) spectroscopy, differential scanning 
      calorimetry (DSC), dynamic shear testing, and an in vitro human osteoblast cell 
      study. The esterification reaction between HA and functionalized HDPE resulted in 
      semicrystalline, insoluble powder. The dynamic shear properties of HA-co-HDPE 
      concentrated solutions were more like natural proteoglycans than the HA control. 
      HA-co-HDPE was successfully compression molded into disks that swelled upon 
      hydration. Osteoblasts were viable and expressed the osteoblast phenotype after 7 
      days of culture on HA-co-HDPE materials. These HA-co-HDPE materials may have 
      several biomaterial applications in saline suspension or molded form, including 
      orthopedic tissue repair.
FAU - Floreani, Rachael
AU  - Floreani R
AD  - Department of Mechanical Engineering, Colorado State University, Fort Collins, 
      Colorado 80523-1374.
FAU - Cranson, Cody N
AU  - Cranson CN
AD  - Department of Mechanical Engineering, Colorado State University, Fort Collins, 
      Colorado 80523-1374.
FAU - James, Susan P
AU  - James SP
AD  - Department of Mechanical Engineering, Colorado State University, Fort Collins, 
      Colorado 80523-1374.
AD  - School of Biomedical Engineering, Colorado State University, Fort Collins, 
      Colorado 80523-1376.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polymers)
RN  - 0 (Proteoglycans)
RN  - 9002-88-4 (Polyethylene)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Biocompatible Materials/*chemistry
MH  - Cells, Cultured
MH  - Esterification
MH  - Humans
MH  - Hyaluronic Acid/*chemistry
MH  - Molecular Mimicry
MH  - Osteoblasts/cytology
MH  - Polyethylene/*chemistry
MH  - Polymers/*chemistry
MH  - Proteoglycans
MH  - Tissue Engineering/*methods
EDAT- 2010/06/29 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 10.1002/jbm.b.31672 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2010 Aug;94(2):441-446. doi: 
      10.1002/jbm.b.31672.