PMID- 20584570
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20151119
IS  - 1873-6327 (Electronic)
IS  - 0306-4603 (Linking)
VI  - 35
IP  - 10
DP  - 2010 Oct
TI  - The frontal assessment battery (FAB) reveals neurocognitive dysfunction in 
      substance-dependent individuals in distinct executive domains: Abstract 
      reasoning, motor programming, and cognitive flexibility.
PG  - 875-81
LID - 10.1016/j.addbeh.2010.05.005 [doi]
AB  - Substance-dependence is highly associated with executive cognitive function (ECF) 
      impairments. However, considering that it is difficult to assess ECF clinically, 
      the aim of the present study was to examine the feasibility of a brief 
      neuropsychological tool (the Frontal Assessment Battery - FAB) to detect specific 
      ECF impairments in a sample of substance-dependent individuals (SDI). Sixty-two 
      subjects participated in this study. Thirty DSM-IV-diagnosed SDI, after 2weeks of 
      abstinence, and 32 healthy individuals (control group) were evaluated with FAB 
      and other ECF-related tasks: digits forward (DF), digits backward (DB), Stroop 
      Color Word Test (SCWT), and Wisconsin Card Sorting Test (WCST). SDI did not 
      differ from the control group on sociodemographic variables or IQ. However, SDI 
      performed below the controls in DF, DB, and FAB. The SDI were cognitively 
      impaired in 3 of the 6 cognitive domains assessed by the FAB: abstract reasoning, 
      motor programming, and cognitive flexibility. The FAB correlated with DF, SCWT, 
      and WCST. In addition, some neuropsychological measures were correlated with the 
      amount of alcohol, cannabis, and cocaine use. In conclusion, SDI performed more 
      poorly than the comparison group on the FAB and the FAB's results were associated 
      with other ECF-related tasks. The results suggested a negative impact of alcohol, 
      cannabis, and cocaine use on the ECF. The FAB may be useful in assisting 
      professionals as an instrument to screen for ECF-related deficits in SDI.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Cunha, Paulo Jannuzzi
AU  - Cunha PJ
AD  - Department and Institute of Psychiatry, University of Sao Paulo, SP, Brazil. 
      pjcunha@usp.br
FAU - Nicastri, Sergio
AU  - Nicastri S
FAU - de Andrade, Arthur Guerra
AU  - de Andrade AG
FAU - Bolla, Karen I
AU  - Bolla KI
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100602
PL  - England
TA  - Addict Behav
JT  - Addictive behaviors
JID - 7603486
SB  - IM
MH  - Adult
MH  - Alcohol Drinking/adverse effects
MH  - Alcoholism/complications
MH  - Case-Control Studies
MH  - Cocaine-Related Disorders/complications
MH  - Cognition Disorders/*etiology/physiopathology
MH  - Executive Function/*physiology
MH  - Feasibility Studies
MH  - Humans
MH  - Male
MH  - Marijuana Abuse/complications
MH  - *Neuropsychological Tests
MH  - Prefrontal Cortex/*physiology
MH  - *Severity of Illness Index
MH  - Substance-Related Disorders/*complications
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/06/30 06:00
MHDA- 2011/07/13 06:00
CRDT- 2010/06/30 06:00
PHST- 2009/11/09 00:00 [received]
PHST- 2010/04/21 00:00 [revised]
PHST- 2010/05/25 00:00 [accepted]
PHST- 2010/06/30 06:00 [entrez]
PHST- 2010/06/30 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - S0306-4603(10)00145-0 [pii]
AID - 10.1016/j.addbeh.2010.05.005 [doi]
PST - ppublish
SO  - Addict Behav. 2010 Oct;35(10):875-81. doi: 10.1016/j.addbeh.2010.05.005. Epub 
      2010 Jun 2.