PMID- 20585661
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20240313
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 6
DP  - 2010 Jun 23
TI  - A nested case-control study of intrauterine exposure to persistent organochlorine 
      pollutants in relation to risk of type 1 diabetes.
PG  - e11281
LID - 10.1371/journal.pone.0011281 [doi]
LID - e11281
AB  - BACKGROUND: The incidence of type 1 diabetes in Europe is increasing at a rate of 
      about 3% per year and there is also an increasing incidence throughout the world. 
      Type 1 diabetes is a complex disease caused by multiple genetic and environmental 
      factors. Persistent organochlorine pollutants (POPs) have been suggested as a 
      triggering factor for developing childhood type 1 diabetes. The aim of this 
      case-control study was to assess possible impacts of in utero exposure to POPs on 
      type 1 diabetes. METHODOLOGY/ PRINCIPAL FINDINGS: The study was performed as a 
      case-control study within a biobank in Malmo, a city located in the Southern part 
      of Sweden. The study included 150 cases (children who had their diagnosis mostly 
      before 18 years of age) and 150 controls, matched for gender and day of birth. 
      2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and the major DDT metabolite 
      1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) were used as a 
      biomarkers for POP exposure. When comparing the quartile with the highest 
      maternal serum concentrations of PCB-153 with the other quartiles, an odds ratio 
      (OR) of 0.73 (95% confidence interval [CI] 0.42, 1.27) was obtained. Similar 
      results was obtained for p,p'-DDE (OR 0.56, 95% CI 0.29, 1.08). CONCLUSIONS: The 
      hypothesis that in utero exposure to POPs will trigger the risk for developing 
      type 1 diabetes was not supported by the results. The risk estimates did, 
      although not statistically significant, go in the opposite direction. However, it 
      is not reasonable to believe that exposure to POPs should protect against type 1 
      diabetes.
FAU - Rignell-Hydbom, Anna
AU  - Rignell-Hydbom A
AD  - Division of Occupational and Environmental Medicine, Lund University, Lund, 
      Sweden. anna.rignell-hydbom@med.lu.se
FAU - Elfving, Maria
AU  - Elfving M
FAU - Ivarsson, Sten A
AU  - Ivarsson SA
FAU - Lindh, Christian
AU  - Lindh C
FAU - Jonsson, Bo A G
AU  - Jonsson BA
FAU - Olofsson, Per
AU  - Olofsson P
FAU - Rylander, Lars
AU  - Rylander L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100623
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - CIW5S16655 (DDT)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - DDT/*toxicity
MH  - Diabetes Mellitus, Type 1/*etiology
MH  - *Environmental Exposure
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Humans
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
PMC - PMC2890585
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2010/06/30 06:00
MHDA- 2011/01/14 06:00
PMCR- 2010/06/23
CRDT- 2010/06/30 06:00
PHST- 2010/02/23 00:00 [received]
PHST- 2010/05/16 00:00 [accepted]
PHST- 2010/06/30 06:00 [entrez]
PHST- 2010/06/30 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
PHST- 2010/06/23 00:00 [pmc-release]
AID - 10-PONE-RA-16518R1 [pii]
AID - 10.1371/journal.pone.0011281 [doi]
PST - epublish
SO  - PLoS One. 2010 Jun 23;5(6):e11281. doi: 10.1371/journal.pone.0011281.