PMID- 20589531
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20130530
IS  - 1573-9686 (Electronic)
IS  - 0090-6964 (Linking)
VI  - 38
IP  - 12
DP  - 2010 Dec
TI  - Right ventricular inefficiency in repaired tetralogy of Fallot: proof of concept 
      for energy calculations from cardiac MRI data.
PG  - 3674-87
LID - 10.1007/s10439-010-0107-2 [doi]
AB  - Repaired tetralogy of Fallot (rTOF) patients develop right ventricular (RV) 
      dilatation and dysfunction. To prevent their demise, pulmonary valve replacement 
      is necessary, though appropriate timing for it is challenged by a paucity of 
      reliable diagnostic parameters. In this pilot study, we hypothesized that stroke 
      work (SW) and energy calculations would delineate the inefficiency of RV 
      performance in rTOF. RV SW was calculated for both an rTOF and a normal subject 
      by utilizing RV pressure and volume measurements obtained during cardiac 
      catheterization and MRI studies. Energy transfer rate and ratio were computed at 
      the main pulmonary artery (PA). Compared to the normal RV, the rTOF RV had higher 
      operating pressure, lower computed SW (0.078 J vs. 0.115 J for normal), and 
      higher negative energy transfer at the PA (0.044 J vs. 0.002 J for normal). 
      Furthermore, the energy transfer ratio was nearly twice as high for the normal RV 
      (1.06) as for the rTOF RV (0.56). RV SW and energy transfer ratio delineate 
      important operational efficiency differences in blood flow from the RV to the PA 
      between rTOF and normal subjects. Our pilot data suggest that the rTOF RV is 
      significantly less efficient than normal.
FAU - Das, Ashish
AU  - Das A
AD  - Department of Mechanical Engineering, University of Cincinnati, OH, USA.
FAU - Banerjee, Rupak K
AU  - Banerjee RK
FAU - Gottliebson, William M
AU  - Gottliebson WM
LA  - eng
PT  - Journal Article
DEP - 20100630
PL  - United States
TA  - Ann Biomed Eng
JT  - Annals of biomedical engineering
JID - 0361512
SB  - IM
MH  - Biomedical Engineering
MH  - Child, Preschool
MH  - Coronary Circulation
MH  - Female
MH  - Heart Valve Prosthesis Implantation
MH  - Heart Ventricles/physiopathology
MH  - Humans
MH  - Hydrodynamics
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Pilot Projects
MH  - Pulmonary Valve/physiopathology/surgery
MH  - Retrospective Studies
MH  - Stroke Volume/physiology
MH  - Tetralogy of Fallot/*physiopathology/surgery
MH  - Ventricular Dysfunction, Right/*physiopathology
EDAT- 2010/07/01 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/03/26 00:00 [received]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - 10.1007/s10439-010-0107-2 [doi]
PST - ppublish
SO  - Ann Biomed Eng. 2010 Dec;38(12):3674-87. doi: 10.1007/s10439-010-0107-2. Epub 
      2010 Jun 30.