PMID- 20592351
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20101118
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 30
IP  - 5
DP  - 2010 May
TI  - Coexpression of MAGE-A peptides and HLA class I molecules in hepatocellular 
      carcinoma.
PG  - 1617-23
AB  - Melanoma antigen (MAGE)-A derived peptides are tumour-specific and induce a 
      strong in vitro T-cell response, if presented with human leukocyte antigen (HLA) 
      molecules, which are involved in T-cell-mediated immune surveillance. 
      MAGE-A-derived peptides are recognised by autologous cytotoxic T lymphocytes. The 
      MAGE-A expression profile of hepatocellular carcinomas (HCC) was analysed by PCR 
      assay covering MAGE-A transcripts in 13 patients. MAGE-A peptide expression was 
      determined using a reverse transcription-PCR method. Cryostat sections were 
      stained with monoclonal antibodies directed against HLA class I molecules. Twelve 
      (92.3%) out of thirteen tumours expressed one MAGE-A gene. In at least 90% of the 
      tumours, one MAGE-A peptide was expressed. Determination of the HLA status of the 
      tumours showed a significant loss in approximately 40% of the tumours. The 
      tumour-specific expression of MAGE genes and antigens encoded by a MAGE-family 
      gene may represent useful targets for tumour-specific immunotherapy in HCC 
      patients, in addition to established treatment options.
FAU - Roch, Nadine
AU  - Roch N
AD  - Department of General, Visceral and Thoracic Surgery, University Medical Centre 
      of Hamburg-Eppendorf, Hamburg, Germany.
FAU - Kutup, Asad
AU  - Kutup A
FAU - Vashist, Yogesh
AU  - Vashist Y
FAU - Yekebas, Emre
AU  - Yekebas E
FAU - Kalinin, Viktor
AU  - Kalinin V
FAU - Izbicki, Jakob R
AU  - Izbicki JR
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Melanoma-Specific Antigens)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Aged
MH  - Antibodies, Monoclonal/chemistry
MH  - Antigens, Neoplasm/*biosynthesis/metabolism
MH  - Carcinoma, Hepatocellular/*metabolism
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Histocompatibility Antigens Class I/*biosynthesis
MH  - Humans
MH  - Immunotherapy/methods
MH  - Liver Neoplasms/*metabolism
MH  - Male
MH  - Melanoma-Specific Antigens
MH  - Middle Aged
MH  - Models, Biological
MH  - Neoplasm Proteins/*biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2010/07/02 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 30/5/1617 [pii]
PST - ppublish
SO  - Anticancer Res. 2010 May;30(5):1617-23.