PMID- 20592921
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220330
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Print)
IS  - 2092-7355 (Linking)
VI  - 2
IP  - 3
DP  - 2010 Jul
TI  - Beef-induced anaphylaxis confirmed by the basophil activation test.
PG  - 206-8
LID - 10.4168/aair.2010.2.3.206 [doi]
AB  - Beef allergies are relatively rare, especially in adults. However, clinical 
      manifestations can vary from urticaria, angioedema, anaphylaxis to 
      gastrointestinal symptoms. Currently available tests, such as skin testing or in 
      vitro determination of beef-specific immunoglobulin E (IgE), do not provide an 
      accurate diagnosis of beef allergy. The recent development of the basophil 
      activation test (BAT) presents a new opportunity for the diagnosis of food 
      allergies. Here, we report a 37-year-old woman with a history of recurrent 
      generalised urticaria, nausea, vomiting and hypotension after ingestion of beef, 
      suggesting a beef allergy. Although the skin prick test and serum specific IgE to 
      beef, pork and milk allergens showed negative results using commercial kits, the 
      BAT showed significant upregulation of CD203c in a dose-dependent manner compared 
      to both non-atopic and atopic controls. To our knowledge, this is the first case 
      study of beef allergy consisting of a non-IgE-mediated reaction. The detection of 
      food allergies using direct basophil activation is suggested to complement 
      conventional diagnostic tests.
FAU - Kim, Joo-Hee
AU  - Kim JH
AD  - Department of Allergy and Rheumatology, Ajou University School of Medicine, 
      Suwon, Korea.
FAU - An, Soyeon
AU  - An S
FAU - Kim, Jeong Eun
AU  - Kim JE
FAU - Choi, Gil-Soon
AU  - Choi GS
FAU - Ye, Young-Min
AU  - Ye YM
FAU - Park, Hae-Sim
AU  - Park HS
LA  - eng
PT  - Journal Article
DEP - 20100504
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC2892054
OTO - NOTNLM
OT  - Beef allergy
OT  - CD203c, human
OT  - basophil activation test
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2010/07/02 06:00
MHDA- 2010/07/02 06:01
PMCR- 2010/07/01
CRDT- 2010/07/02 06:00
PHST- 2010/02/21 00:00 [received]
PHST- 2010/04/09 00:00 [accepted]
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/07/02 06:01 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - 10.4168/aair.2010.2.3.206 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2010 Jul;2(3):206-8. doi: 10.4168/aair.2010.2.3.206. 
      Epub 2010 May 4.