PMID- 20594764
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20111117
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 35
IP  - 10
DP  - 2010 Nov
TI  - Voluntary exercise and palatable high-fat diet both improve behavioural profile 
      and stress responses in male rats exposed to early life stress: role of 
      hippocampus.
PG  - 1553-64
LID - 10.1016/j.psyneuen.2010.05.012 [doi]
AB  - Childhood trauma induced by adverse early life experience is associated with 
      increased risk of psychological disorders in adulthood. Disruption of normal 
      development has been shown to affect hippocampal morphology and function, 
      influencing adaptations to stress. Here we investigated whether palatable food 
      and/or exercise would ameliorate the behavioural responses following early life 
      stress in rats. Rats were subjected to 15 (S15) or 180 (S180) minutes separation 
      from dams on postnatal days 2-14. After weaning, rats were assigned to either 
      receive chow (C), high-fat diet (HFD), voluntary exercise (running, R), or 
      combined HFD and R for 11 weeks. In addition to anxiety- and depression-like 
      behaviours, response to restraint stress was measured. Glucocorticoid receptor 
      (GR), brain-derived neurotrophic factor (BDNF) and 5-hydroxytryptamine receptor 
      1A (5HT1A) receptor mRNA in the hippocampus were measured. S180 rats had similar 
      body weight to S15, however their plasma insulin concentrations were double those 
      of S15 rats when consuming HFD; adding exercise reduced plasma insulin. 
      Anxiety-like behaviour in S180 rats, measured using Light Dark test (LDT) and 
      Elevated Plus Maze (EPM) were ameliorated by the provision of HFD, R or HFD+R. A 
      similar effect was observed on depression-like behaviour assessed by forced swim 
      test (FST), with less time being spent immobile. Exposure to early-life stress 
      during development was associated with significant reductions in hippocampal GR, 
      5HT1A receptor and BDNF mRNA, and these changes were normalized in S180 rats 
      provided with HFD or exercise. Prolonged maternal separation resulted in 
      exacerbated hyperinsulinemia when consuming HFD suggesting that these rats are 
      metabolically disadvantaged. In summary, voluntary exercise alone or in 
      combination with HFD produced beneficial effects on both behaviour and metabolic 
      outcomes in rats exposed to early life stress.
CI  - Crown Copyright (c) 2010. Published by Elsevier Ltd. All rights reserved.
FAU - Maniam, Jayanthi
AU  - Maniam J
AD  - School of Medical Sciences, University of New South Wales, NSW 2052, Australia.
FAU - Morris, Margaret J
AU  - Morris MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100701
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dietary Fats)
RN  - 0 (Insulin)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
SB  - IM
MH  - Animals
MH  - Anxiety/psychology
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/biosynthesis
MH  - Darkness
MH  - Diet
MH  - Dietary Fats/*pharmacology
MH  - Female
MH  - Hippocampus/*physiopathology
MH  - Hypothalamo-Hypophyseal System/physiopathology
MH  - Insulin/blood
MH  - Light
MH  - Male
MH  - Physical Conditioning, Animal/*psychology
MH  - Pituitary-Adrenal System/physiopathology
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT1A/biosynthesis
MH  - Receptors, Glucocorticoid/biosynthesis
MH  - Restraint, Physical
MH  - Stress, Psychological/*psychology
MH  - Swimming/psychology
EDAT- 2010/07/03 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/03/18 00:00 [received]
PHST- 2010/05/31 00:00 [revised]
PHST- 2010/05/31 00:00 [accepted]
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - S0306-4530(10)00142-3 [pii]
AID - 10.1016/j.psyneuen.2010.05.012 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2010 Nov;35(10):1553-64. doi: 
      10.1016/j.psyneuen.2010.05.012. Epub 2010 Jul 1.